Lectures and seminars CBB biostatistics seminar: "Comparison of time-dependent treatments in presence of multiple time-scales: an application in stem cells transplantation" - Simona Iacobelli

Before the seminar, a limited number of sandwiches and drinks will be served on a “First come – first served” basis starting 12:00. Show up early and network!

The seminar is held in English.

 Abstract

Treatments for potentially life-threatening chronic diseases often present a trade-off between safety and efficacy. In many situations a first treatment is followed after some time by an intensifying intervention, or more simply the wait-and-see approach is abandoned starting a treatment characterized by increased mortality in the short term. The comparison of long-term outcomes in absence of randomization or intent-to-treat is complicated by the time-dependency of the treatment and the time-varying effects. In this study we focus in particular on the relevance of multiple time-scales (time from first treatment and time from second treatment). The motivating example belong to research in stem cell transplant.