Excess body fat increases risk of digestive system cancers
Obesity increases the risk of developing cancers of the digestive system and it is the person’s fat mass, rather than size, that is the main obesity-related risk factor for these cancer types, according to a new study published in the journal PLOS Medicine by researchers at the University of Cambridge and Karolinska Institutet.
Fetal development of the brain identified down to the smallest detail
Researchers at Karolinska Institutet have developed a detailed molecular atlas of the fetal development of the brain. The study published in the top journal Nature is based on so-called single-cell technology and has been done on mice. In this way, researchers have identified almost 800 different cells that are active during fetal development – many times more than previously known.
3D imaging reveals neural ‘vicious cycle’ in fatty liver disease
With the application of a novel three-dimensional imaging technology, researchers at Karolinska Institutet have discovered that one portion of the autonomic nervous system in the liver undergoes severe degeneration in non-alcoholic fatty liver disease. The study, which is published in Science Advances, shows that the degeneration of nerves is correlated with the severity of liver pathology.
Strengthened collaboration with Hungary in the field of cancer
Karolinska Institutet has signed a collaborative agreement with the Hungarian National Institute of Oncology, NIO. The planned collaboration will primarily take place within the framework of Karolinska Comprehensive Cancer Centre together with Karolinska University Hospital.
Karolinska Institutet backs call for the release of Dr. Ahmadreza Djalali
The International Community must race to secure Dr. Ahmadreza Djalali’s immediate release and his subsequent access to medical care. Karolinska Institutet backs the call upon the European Union, European state governments, and the United States government to act immediately to save Dr. Djalali before it is too late.
Fear reactions of others recover our own memories of danger
Both humans and other animals learn quickly about dangers in their environment by observing the behavior of other individuals. Researchers at Karolinska Institutet now show that both rats and humans can use such social information to reactivate memories about threats that have been previously acquired through their own experiences.
The frequency of incorrectly attributed paternity is lower than previously thought
Determining who is the biological father of a child is a sensitive subject, but the answer can be crucial in important issues. In a nationwide study published in the Journal of Internal Medicine, researchers from Karolinska Institutet, by using two different models, have been able to show that the proportion of incorrectly established paternities in Sweden is as low as 1.7 percent, a figure that has decreased over time.
The new coronavirus
Genetic risk factors for severe COVID-19 identified
In March 2020, thousands of researchers across the globe joined forces to answer the question of why some COVID-19 patients develop a severe, life-threatening disease, while others manage with mild or no symptoms. A comprehensive summary of their findings to date, based on the analyses of nearly 50,000 patients and published in Nature today, reveals 13 genetic regions that are strongly associated with infection or severe COVID-19.
New biomarkers for life-threatening soft tissue infections
Rapid diagnosis is crucial in bacterial soft tissue infections to reduce the risk of severe injury or amputation. Vague symptoms and a heterogeneous patient group increase the risk of misdiagnosis. Researchers at Karolinska Institutet and other research institutions have now, with the help of AI, identified a new and very promising biomarker. The study, published in the Journal of Clinical Investigation, may have implications for both diagnosis and treatment.
Hunter-gatherer groups identify sick Europeans without difficulty
The evolutionary ability to identify sick individuals is crucial to reducing contagion and thereby improving chances of survival. Although most animals have this ability, whether humans have the same behavioural immune system has long been a subject of discussion. Researchers at KI have now proven that hunter-gatherer groups can identify the sick from Western Europe.
New genetic knowledge about cluster headache
Researchers at Karolinska Institutet, together with British colleagues, have conducted the largest study to date in search of genetic markers about cluster headache. In the long term, it can hopefully pave the way for more effective treatments. The study is published in the scientific journal Annals of Neurology.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
New method to analyse direct cell-cell interaction in tissue
An unsupervised method for physical cell interaction profiling of complex tissues, Andrews N et al, Nature Methods, July 2021.
Challenges and opportunities for treatment of PCOS
Epigenetic inheritance of polycystic ovary syndrome – challenges and opportunities for treatment, Stener-Victorin E, Deng Q, Nature Reviews Endocrinology, July 2021.
Increased mortality among children and young adults with fatty liver
Non-alcoholic fatty liver disease in children and young adults is associated with increased long-term mortality, Simon TG et al, Journal of Hepatology, July 2021.
New insights on exercise adaptation at a molecular level
Time trajectories in the transcriptomic response to exercise — a meta-analysis, Amar D, Lindholm ME, Norrbom J, Wheeler MT, Rivas MA, Ashley EA, Nature Communications, June 2021.
More high impact publications
KI in the media
The Macchiarini case: timeline
Creating a better future for all children
Professor Stefan Swartling Peterson isn’t interested in getting more papers published. No, he wants to spend the last ten years of his career helping to create a better future for all children. And time’s running out.
The Conversation: COVID during pregnancy poses a low risk to newborns
According to KI researcher Mikael Norman, babies born to women who have tested positive for COVID-19 do not need to be routinely separated from their mothers at birth. Find this news article and others from KI, recently published by the news site The Conversation.
Spotlight on Vaccine Research
Vaccines have saved lives for more than 200 years, but the research area continues to evolve with new discoveries that provide more effective and safer vaccines. Doors are now opening to develop vaccines against, for example, cancer, dementia and cardiovascular disease. The COVID-19 pandemic has given vaccine research a real boost.