Online CBT effective for social anxiety disorder in young people
Social anxiety disorder can cause considerable suffering in children and adolescents and, for many with the disorder, access to effective treatment is limited. Researchers at Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm have now shown that internet-delivered cognitive behavioural therapy is an efficacious and cost-effective treatment option. The study is published in the journal JAMA Psychiatry.
New findings linking brain immune system to psychosis
New research at Karolinska Institutet suggests a link between psychosis and a genetic change that affects the brain's immune system. The study published in Molecular Psychiatry may impact the development of modern medicines for bipolar disorder or schizophrenia.
Online CBT effective against OCD symptoms in the young
Obsessive-compulsive disorder (OCD) in children and adolescents is associated with impaired education and worse general health later in life. Access to specialist treatment is often limited. According to a study from Centre for Psychiatry Research at Karolinska Institutet and Region Stockholm, internet-delivered cognitive behavioural therapy (CBT) can be as effective as conventional CBT. The study, published in the prestigious journal JAMA, can help make treatment for OCD more widely accessible.
Microneedle patch delivers antibiotics locally in the skin
MRSA skin infections are often treated with intravenous injection of antibiotics, which can cause significant side effects and promote the development of resistant bacterial strains. To solve these problems, researchers at Karolinska Institutet are developing a microneedle patch that delivers antibiotics directly into the affected skin area. New results published in Advanced Materials Technologies show that the microneedle patch effectively reduces MRSA bacteria in the skin.
Serotonin transporters increase when depression fades, study shows
Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells. A brain imaging study at Karolinska Institutet now shows that the average level of the serotonin transporter increased in a group of 17 individuals who recovered from depression after cognitive behavioural therapy. The results are published in the journal Translational Psychiatry.
The new coronavirus
KI receives SEK 6.5 million in funding for COVID-19 research
Thirteen KI researchers have received funding from the Heart-Lung Foundation for their research on the new coronavirus. The grants total SEK 6.5 million, with approximately 40 per cent of the grants being distributed by the Heart-Lung Foundation (2021).
Large study links dementia to poor kidney function
Older people with kidney disease have a higher risk of dementia, and the risk increases with the rate and stage of kidney function decline. That is according to a large observational study by researchers at Karolinska Institutet, published in Neurology. The findings stress the significance of screening and monitoring for dementia in persons with kidney disease, the researchers say.
New marker predicts benefit of radiotherapy for early-stage breast cancer
A study involving researchers at Karolinska Institutet and University of Gothenburg has found that low levels of a protein called PDGFRb are associated with particularly good results of radiotherapy in women with early-stage breast cancer. The study, which is published in the journal Clinical Cancer Research, also suggests that the efficacy of radiotherapy can be improved with drugs that block this protein.
Intestinal polyps in close relatives can increase risk of colorectal cancer
Cancer of the colon and rectum is one of the deadliest forms of cancer, and has in recent years affected growing numbers of young people. In the largest registry study to date, researchers at Karolinska Institutet and Harvard University in the USA demonstrate a possible connection between colorectal polyps in close relatives and the risk of developing colorectal cancer. The study, which is published in The British Medical Journal, is of potential consequence for screening procedures.
New findings on barriers and support in global fight against tuberculosis
Nine out of ten cases of tuberculosis appear in 30 identified low and middle-income countries, each of which has a national tuberculosis programme. The managers of these programmes agree that it is important to screen for tuberculosis outside of health facilities. However, each screening programme must have its own well-considered, sustainable strategy and sufficient resources for it to be meaningful – which is not always the case today. This is one conclusion drawn by Olivia Biermann’s thesis.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
Severe COVID-19 may be driven by RAAS imbalance
COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system, Susanne Rysz et al, Nature Communications, April 2021.
One step closer toward understanding the origin of neuroblastoma
Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin, Polina Kameneva et al, Nature Genetics, April 2021.
Personalized care the way forward to reduce obesity and type 2 diabetes
Metabolic Consequences of Obesity and Type 2 Diabetes: Balancing Genes and Environment for Personalized Care, Nicolas J. Pillon et al, Cell, March 2021.
Neandertal protein variant may protect Europeans against COVID-19
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity, Hugo Zeberg et al, Nature Medicine, February 2021.
Severe COVID-19 more common in patients with collagenous colitis
Association Between Collagenous and Lymphocytic Colitis and Risk of Severe COVID-19, Hamed Khalili et al, Gastroenterology, February 2021.
More high impact publications
KI in the media
The Macchiarini case: timeline
She wants to understand long-term COVID
As a tuberculosis researcher, she is accustomed to studying airborne pandemic contagion. Early in the current pandemic, Judith Bruchfeld saw the need to assemble various experts to investigate long-term illness after COVID-19. “There’s a lot we don’t understand yet.”
The Conversation: COVID during pregnancy poses a low risk to newborns
According to KI researcher Mikael Norman, babies born to women who have tested positive for COVID-19 do not need to be routinely separated from their mothers at birth. Find this news article and others from KI, recently published by the news site The Conversation.
Spotlight on Vaccine Research
Vaccines have saved lives for more than 200 years, but the research area continues to evolve with new discoveries that provide more effective and safer vaccines. Doors are now opening to develop vaccines against, for example, cancer, dementia and cardiovascular disease. The COVID-19 pandemic has given vaccine research a real boost.