Study explains the process that exacerbates MS
People with multiple sclerosis (MS) gradually develop increasing functional impairment. Researchers at Karolinska Institutet have now found a possible explanation for the progressive course of the disease in mice and how it can be reversed. The study, which is published in Science Immunology, can prove valuable to future treatments.
Even mild fatty liver disease is linked to increased mortality
Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the scientific journal Gut.
Nobel Prize 2020
KI researchers comment on the 2020 Nobel Prize in Chemistry: “Fantastic, at last!”
The Royal Swedish Academy of Scientists have decided to award the 2020 Nobel Prize in Chemistry to Emmanuelle Charpentier and Jennifer A. Doudna. Here, KI researchers who uses the method in their own research comment on this year’s prize. “It’s what we’ve been waiting for,” says Fredrik Lanner.
New center focus on integrated science
Karolinska Institutet, in collaboration with KTH - Royal Institute of Technology in Stockholm, inaugurated a new research centre on 30 September. The aim of the centre, called AIMES – Center for the Advancement of Integrated Medical and Engineering Sciences, is to promote inter-disciplinary research and its translation to societal impact.
New clues about the link between stress and depression
Researchers at Karolinska Institutet have identified a protein in the brain that is important both for the function of the mood-regulating substance serotonin and for the release of stress hormones, at least in mice. The findings, which are published in the journal Molecular Psychiatry, may have implications for the development of new drugs for depression and anxiety.
Stem cells can help repair spinal cord after injury
Spinal cord injury often leads to permanent functional impairment. In a new study published in the journal Science researchers at Karolinska Institutet show that it is possible to stimulate stem cells in the mouse spinal cord to form large amounts of new oligodendrocytes, cells that are essential to the ability of neurons to transmit signals, and thus to help repair the spinal cord after injury.
HPV vaccine effective against cervical cancer
Women vaccinated against HPV have a significantly lower risk of developing cervical cancer, and the positive effect is most pronounced for women vaccinated at a young age. That is according to a large study by researchers at Karolinska Institutet in Sweden published in New England Journal of Medicine.
The new coronavirus
Neandertal gene variant increases risk of severe COVID-19
A study published in Nature shows that a segment of DNA that causes their carriers to have an up to three times higher risk of developing severe COVID-19 is inherited from Neandertals. The study was conducted by researchers at Karolinska Institutet and Max Planck Institute for Evolutionary Anthropology.
Almost SEK143 million in KAW project grants
Four major research projects at Karolinska Institutet are to receive project grants from the Knut and Alice Wallenberg Foundation (KAW) this year. A total of almost SEK 143 million over a five-year period is to be invested in KI projects on cellular ageing, cerebral decision-making mechanisms, stem-cell fate and antibody-producing cells.
A limited selection of recent publications in high impact journals to which researchers at KI have contributed.
Dopamine regulates synchronicity in the activity of striatal neurons
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner, Matthijs C. Dorst, et al, Nature Communications, October 2020.
Promising results in case study of COVID-19 drug candidate APN01
Human recombinant soluble ACE2 in severe COVID-19, Ali Mirazimi et al, The Lancet Respiratory Medicine, September 2020.
New knowledge on the effect of periodic fasting in over-weight men
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression, Lundell LS, Nature Communications, September 2020.
KI in the media
The Macchiarini case: timeline
Professors' inauguration 2020
On 15 October 2020, fourteen new professors were inaugurated at Karolinska Institutet in solemn forms in Aula Medica. The professors' inauguration ceremony is one of the highlights of the academic year of our university. This year due to the pandemic, the ceremony was partly held digitally.
Ten questions (plus one extra) for KI’s new chairman of the university board
In a sense, Göran Stiernstedt will have come full circle when he takes up office as KI chairperson on 1 May 2020. He once took his medical degree at KI, and now he’s back.
Spotlight on COVID-19
In early 2020, a new coronavirus was identified in China, and it has now caused a worldwide pandemic. The official name for this virus is SARS-CoV-2, and the disease that is caused by the virus is called COVID-19. Here we present news and features about KI's efforts to stop the new coronavirus.