Cheap drug may alleviate treatment-resistance in leukemia
A common drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), according to a study in mice and human blood cells published in the medical journal EMBO Molecular Medicine. The researchers will now launch a clinical study to test the new combination treatment in patients.
New discovery on function of MAIT cells during acute HIV infection
In a study in Nature Communications, researchers at Karolinska Institutet show that MAIT cells respond with dynamic activity and reprogramming of gene expression during the initial phase of HIV infection. The study fills a knowledge gap, as previously there has been a lack of awareness of the function of MAIT cells during this particular phase.
Long-term medication for schizophrenia is safe
Researchers at Karolinska Institutet and their colleagues in Germany, the USA and Finland have studied the safety of very long-term antipsychotic therapy for schizophrenia. According to the study, which is published in the scientific journal World Psychiatry, mortality was higher during periods when patients were not on medication than when they were.
Colorectal cancer risk remains despite modern treatment for ulcerative colitis
Patients with the inflammatory bowel disease ulcerative colitis have a higher risk of dying from colorectal cancer, despite modern therapy, even though the risk has declined in recent years. This is according to a new study published in the scientific journal The Lancet by a team of Swedish and Danish researchers.
AI can be used to detect and grade prostate cancer
Researchers have developed a method based on artificial intelligence for histopathological diagnosis and grading of prostate cancer. The study, presented in The Lancet Oncology, shows that the AI-system is as good at identifying and grading prostate cancer as world-leading uro-pathologists. The technology has the potential to solve one of the bottlenecks in today’s prostate cancer.
Washing proteins with soap reveals new clues for drug development
Using a trick involving detergent and mass spectrometry, a research group has been able to wash and weigh protein molecules to determine which lipids make the protein work. The findings may help design molecules that stick to individual membrane proteins and pave the way for the development of new drugs including antibiotics and cancer therapies. The study is published in Angewandte Chemie International Edition.
A molecular map of the brain’s decision-making area
Researchers at Karolinska Institutet have come one step closer toward understanding how the part of our brain that is central for decision-making and the development of addiction is organized on a molecular level. Their spatiomolecular map, now in Cell Reports, may further our understanding of the brain’s reward-system.
Detailed map of immune cells in human blood
Researchers at SciLifeLab report in the journal Science that they have created a detailed blood atlas of the proteins in human immune cells. The open-access database offers medical researchers an unprecedented resource in the search for treatments for diseases.
A limited selection of recent publications in high impact journals where researchers from KI are main authors.
Increased risk of IBD among patients with microscopic colitis
Microscopic Colitis and Risk of Inflammatory Bowel Disease in a Nationwide Cohort Study, Khalili H et al, Gastroenterology, Jan 2020.
Suicide rates decline worldwide except in the US
Suicide, Fazel S, Runeson B, NEJM, Jan 2020.
Genes predict tamoxifen treatment outcome in breast cancer
CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer, He W et al, Journal of Clinical Oncology, Dec 2019.