| Karolinska Institutet Nyheter

Early food introduction can reduce risk of food allergy in children

Infants who were given a taste of peanut, milk, wheat and egg from the age of three months had a lower risk of developing a food allergy at the age of three years than controls, reports a study by researchers from Karolinska Institutet in Sweden and the University of Oslo in Norway published in The Lancet.

New approach to treatment of deadly kidney cancer

Researchers at Karolinska Institutet have linked resistance to treatment for a deadly form of kidney cancer to low mitochondrial content in the cell. When the researchers increased the mitochondrial content with an inhibitor, the cancer cells responded to the treatment. Their findings, which are published in Nature Metabolism, offer hope for more targeted cancer drugs.

Improved protein function opens way for new drug development concept

Researchers at Karolinska Institutet and SciLifeLab describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function. Their innovative technique can lead to improved drugs for diseases involving oxidative stress, such as cancer, Alzheimer’s disease and lung diseases, but the researchers believe it has even greater potential.

Successful repatriation of remains to North America

On May 18, Dan Jibréus, who travelled to North America on behalf of the KI to return the remains of two persons, returned to Sweden. He describes the trip as very successful, and the two remains, from the Arikara and Miami peoples respectively, have now been returned to their places of origin.

Three KI researchers among the “Future research leaders“

The Swedish Foundation for Strategic Research, SSF, has appointed the eight generation of "Future research leader", three researchers from Karolinska Institutet. The researchers receive 15 million SEK each during a five year period and will join a leadership training program.

LGBTQI-inclusive work and study environment in focus during pride week

As in previous years, several of Stockholm's academic institutions are joining together with a united theme during Pride week to draw attention to LGBTQI issues. Academic Pride 2022 is organising a seminar on LGBTQI-inclusive work and study environments and joint participation in the Pride Parade. The Pride flag will also be flown at all participating universities throughout the week of this festive week.

Diabetes and cardiovascular disease increase dementia risk

People with at least two of the diseases type 2 diabetes, heart disease or stroke have double the risk of developing dementia. Prevention of diabetes and cardiovascular disease could therefore be a strategy for reducing dementia risk, a study from Karolinska Institutet published in the journal Alzheimer’s & Dementia suggests.

Patient-initiated brief admission an important complement to psychiatric outpatient care

Patient-initiated brief admission as a complement to outpatient psychiatric care is appreciated by nurses and patients, and can reduce levels of anxiety in people with emotional instability and self-harm, a new thesis from Karolinska Institutet reports.

The Coronavirus

Omicron elicits lower antibody responses in individuals with prior COVID-19 infection

Researchers at Karolinska Institutet and Danderyd Hospital have followed participants who have received three doses of the SARS-CoV-2 vaccine and compared their immune responses after Omicron infection. The results, which are published in The Lancet Infectious Diseases, show that Omicron infection elicits significantly higher antibody responses in individuals without prior COVID-19 infection as compared to previously infected individuals.

Gene variant influences blood clot risk in severe covid-19

Researchers at Uppsala University and Karolinska Institutet are one step closer to explaining why COVID-19 patients have a substantially increased risk of blood clots. The study, published in Nature Immunology, shows that a gene variant in the innate immune system influences the risk for blood clots in the lungs of severely ill COVID-19 patients.

mRNA booster vaccines may be a good investment in resource-poor countries

Vaccines based on inactivated SARS-CoV-2 virus are commonly used in resource-poor countries due to their low cost. New research from Karolinska Institutet shows that a booster shot of mRNA vaccine to individuals who have received two doses of inactivated vaccine offers the same level of protection against COVID-19 as three doses of mRNA vaccine. The findings are published in the journal Nature Communications.

Air pollution linked to higher risk of COVID-19 in young adults

Residential exposure to ambient air pollutants is linked to an elevated risk of SARS-CoV-2 infection, an observational study of young adults in Stockholm shows. The study was conducted by researchers from Karolinska Institutet and is published in JAMA Network Open.

No increase in pregnancy complications after COVID-19 vaccination

Vaccination against COVID-19 during pregnancy is not associated with a higher risk of pregnancy complications, according to a large-scale registry study from Karolinska Institutet in Sweden and the Norwegian Institute of Public Health published in the journal JAMA.

Antibiotic resistance – the silent pandemic

Can climate worry be used constructively?

The Conversation: 6 ways long-term smell loss can affect us

Top publications in selection

Low socioeconomic status linked to increased risk of bleeding after aortic valve replacement
Dalén M et al, Journal of the American College of Cardiology, June 2022

”Unexpected finding on the 3D organisation of chromosomes”
Björkegren C et al, Science Advances, June 2022

New study on IRF7 protein deficient patients with COVID-19 and influenza
Campbell T et al, Journal of Experimental Medicine, June 2022

A non-coding RNA regulates gene expression in human mitochondria
Xuefeng Zhu et al, Cell, June 2022

New stem cell-based technology opens for possible future treatment in Parkinson’s
Alekseenko Z et al, Nature Communications, June 2022

Improved method for single-cell RNA-sequencing at scale
Hagemann-Jensen M et al, Nature Biotechnology, May 2022

Blocking calcium pump inhibitor as potential treatment for heart failure
De Genst E et al, Nature Communications, May 2022

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Top publications in selection

Early food introduction can reduce risk of food allergy in children

New approach to treatment of deadly kidney cancer

Improved protein function opens way for new drug development concept

Successful repatriation of remains to North America

Three KI researchers among the “Future research leaders“

LGBTQI-inclusive work and study environment in focus during pride week

Diabetes and cardiovascular disease increase dementia risk

Patient-initiated brief admission an important complement to psychiatric outpatient care

The Coronavirus

Omicron elicits lower antibody responses in individuals with prior COVID-19 infection

Gene variant influences blood clot risk in severe covid-19

mRNA booster vaccines may be a good investment in resource-poor countries

Air pollution linked to higher risk of COVID-19 in young adults

No increase in pregnancy complications after COVID-19 vaccination

Antibiotic resistance – the silent pandemic

Can climate worry be used constructively?

The Conversation: 6 ways long-term smell loss can affect us

Top publications in selection

How screen habits affects children's health

Vaccines against COVID-19 and other diseases – how they continue to evolve

Information regarding the war in Ukraine

KI at Almedalen 2022

President‘s blog

The Macchiarini case: timeline

KI in the debate

KI in the media

Research subjects wanted