Published: 21-11-2012 00:00 | Updated: 16-06-2014 15:29

Low muscle strength in adolescence risk factor for early death

Low muscle strength in adolescence is strongly associated with a greater risk of early death from several major causes, according to a large study led from Karolinska Institutet. The findings, which are published in the British Medical Journal (BMJ), suggest that the effect of low muscle strength is similar to well established risk factors for early death like being overweight or having high blood pressure.

High body mass index (BMI) and high blood pressure at a young age are known risk factors for premature death, but whether muscular strength in childhood or adolescence can predict mortality is unclear. So a team of Swedish, Spanish and Finnish researchers, led by Professor Finn Rasmussen at Karolinska Institutet, tracked more than one million Swedish male adolescents aged 16 to 19 years over a period of 24 years.

Participants underwent three reliable muscular strength tests at the start of the study (knee extension strength, handgrip strength and elbow flexion strength). BMI and blood pressure were also measured. Premature death was defined as death before age 55 years. During the follow-up period, 26,145 participants (2.3 percent of the group) died. Suicide was the most common cause of death (22.3 percent) compared with cardiovascular diseases (7.8 percent) or cancer (14.9 percent).

High muscular strength was associated with a 20-35 percent lower risk of early death from any cause and also from cardiovascular diseases, independently of BMI or blood pressure. No association was seen with cancer deaths. Stronger adolescents also had a 20-30 percent lower risk of early death from suicide and were up to 65 percent less likely to have any psychiatric diagnosis, such as schizophrenia and mood disorders. These results suggest that physically weaker individuals might be more mentally vulnerable, say the authors.

In contrast, male adolescents with the lowest level of muscular strength showed the greatest all-cause mortality and also the greatest mortality in cardiovascular disease and suicide before age 55 years. Death rates from any cause (per 100,000 person years) ranged between 122.3 and 86.9 for weakest ad strongest adolescents respectively. Rates for cardiovascular diseases were 9.5 and 5.6 and for suicide were 24.6 and 16.9.

The authors conclude that low muscular strength in adolescents "is an emerging risk factor for major causes of death in young adulthood, such as suicide and cardiovascular diseases." The effect sizes of these associations "are similar to classic risk factors such as body mass index and blood pressure." They support the need for regular physical activity in childhood and adolescence, and also suggest that muscular strength tests, in particular handgrip strength, could be assessed with good reliability in almost any place, including clinical settings, schools and workplaces.

The study was funded by grants from the Swedish Research Council and the Spanish Ministry of Science and Innovation.


Muscular strength in male adolescents and premature death: cohort study of one million participants.
Ortega F, Silventoinen K, Tynelius P, Rasmussen F
BMJ 2012 Nov;345():e7279