Lectures and seminars Webinar: Reduction and refinement of genetically altered mouse breeding - Controlling quality and quantity according to experimental needs

Speaker

Dr. Karim Meshba, Institute of Human Genetics, CNRS, University of Montpellier, France.

Dr. Karim Meshba holds a PhD in Molecular and Developmental Cell Biology and brings over 25 years of experience in generating and analyzing genetically modified mouse models, gained at the Institut Pasteur and the CNRS. He has led both a breeding and assisted reproduction department (Janvier Labs) and a functional exploration facility at the CNRS, managing more than 500 mouse lines. As an expert at the French Ministry of Higher Education and Research, he contributed to the regulation of genetically altered animals. He currently works as a research engineer at the Institute of Human Genetics (CNRS, Montpellier), focusing on genetically modified mouse models to study telomeropathies.

Register here (by April 1, 12.00 PM CEST)

Abstract

Mice are the most widely used animal model in research, yet in Europe, 60% of genetically modified mice produced are never used in experiments. This lecture explores how optimizing transgenic colony management can significantly reduce this waste.

It introduces the DOPPUME framework (Define, Obtain, Protect, Produce, Use, Manage, Exchange) — a structured approach to the rigorous management of genetically modified lines. Key topics include precise model definition aligned with scientific objectives, control of genetic background to prevent drift, and accurate estimation of production needs based on experimental design and breeding schemes. Grounded in the 3Rs principles, DOPPUME provides practical tools for a more responsible and rational use of mouse models in research.

Contact

E-mail: las-edu@km.ki.se