Lectures and seminars Seminar: "Mapping the gene regulatory targets and mechanisms of non-coding autoimmune risk loci in primary B cells"

Dr Hamish King is a Laboratory Head at the Walter and Eliza Hall Institute (WEHI) where his team studies the genetic and gene regulatory principles that underlie health and disease in the human immune system. He completed his PhD in gene regulation at the University of Oxford with Prof Rob Klose where he contributed to seminal studies on non-canonical polycomb repressive complexes. He was then awarded a Sir Henry Wellcome Postdoctoral fellowship to study the gene regulatory networks that define human B cell identity and function at Queen Mary University of London with Dr Louisa James and the Wellcome Sanger Institute with Dr Sarah Teichmann. This led to several influential single-cell genomic studies of human B cell states and immune heterogeneity, including as part of the Human Cell Atlas. Since beginning his lab in 2022, Dr King's work integrates experimental and computational genomics, with an emphasis on working with primary immune cells. Recent discoveries emerging from the King lab include world-first CRISPR activation screens of autoimmune risk loci in primary human B cells, mapping cellular and molecular features of patient cohorts with immune-mediated disease, modelling DNA de-methylation dynamics and mechanistic studies of immune-specific chromatin reader function.

Host

Goncalo Castelo- Branco, Department of Medical Biochemistry and Biophysics, Karolinska Institutet