Lectures and seminars OnkPat Friday Seminar: Highjacked tissue regeneration as a unifying principle of cancer host interaction

Hosts: Andreas Lundqvist, Department of Oncology-Pathology and Mikael Karlsson, Department of Microbiology, Tumor and Cell Biology.

Bio

Ilaria Malanchi obtained her Master degree at the University of Siena after two years spent at the research centre of Chiron Vaccine, (later Novartis Vaccine and now GSK, Siena, Italy). She obtained her PhD from Heidelberg University (Germany), working in the laboratory of Dr Tommasino at the DKFZ. As Dr Tommasino moved his laboratory to France in 2003, she spent one year at the IARC (WHO, Lyon, France).

Her long-standing interest in the complex cancer cellular interaction in vivo began when she moved to the newly opened Joerg Huelsken lab at the ISREC, Lausanne, Switzerland, (now part of the Federal Swiss University (EPFL)), to start her postdoc in 2004. During these Postdoc years she began to investigate the importance of tumour microenvironment during metastatic progression.

Building on this expertise in mouse tumour models, Ilaria set up her laboratory at the Cancer Research UK London Research Institute in 2011 (now part of the Francis Crick Institute) and has since focused the scope of investigation on the interaction between cancer cells and the surrounding tissue during tumorigenesis and metastatic progression. Ilaria was awarded tenure and promoted to Senior Group Leader at the Francis Crick Institute in 2018.

Related publications

Bidirectional activation of stem-like programs between metastatic cancer and alveolar type 2 cells within the niche.
Rodrigues FS, Karoutas A, Ruhland S, Rabas N, Rizou T, Di Blasio S, Ferreira RMM, Bridgeman VL, Goldstone R, Sopena ML, Lee JH, Ombrato L, Malanchi I
Dev Cell 2024 Sep;59(18):2398-2413.e8

Circulating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes.
Ramessur A, Ambasager B, Valle Aramburu I, Peakman F, Gleason K, Lehmann C, Papayannopoulos V, Coombes RC, Malanchi I
Breast Cancer Res 2023 Oct;25(1):125

Metastatic-niche labelling reveals parenchymal cells with stem features.
Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I
Nature 2019 Aug;572(7771):603-608