Lectures and seminars OnkPat Friday Seminar – Fourth-Generation EGFR-TKIs: From Rational Design to Conformational Dynamics of Mutant Kinase Domains
Welcome to an OnkPat Friday Seminar with Cristina Minnelli, researcher at Polytechnic University of Marche. She is an early-career researcher working in medicinal and bioorganic chemistry, with a focus on the design and synthesis of bioactive molecules primarily for cancer therapy.
Host: Domenico Scaramozzino, Department of Oncology-Pathology.
Bio
Cristina Minnelli (34) is an early-career researcher working in medicinal and bioorganic chemistry, with a focus on the design and synthesis of bioactive molecules primarily for cancer therapy. She began her academic training at the Università Politecnica delle Marche (IT), where she completed her Master’s degree in 2015 with full marks and honors. She subsequently obtained her PhD in Biomolecular Sciences in 2019, developing innovative antioxidant and antimicrobial molecules for biomedical applications. Following her doctoral training, she received two grants from the Italian Foundation for Cancer Research (FIRC-AIRC) in 2019 and 2021–2022, through which she developed a research program focused on mutant-selective EGFR tyrosine kinase inhibitors for non-small cell lung cancer (NSCLC).
To date, Cristina has authored 57 peer-reviewed publications (43% as first/co-first or corresponding author), with an h-index of 21 and more than 1,200 citations. She is co-inventor of two granted patents and co-founder of the spin-off BIOSOLVING srl. In 2023, she obtained the Italian National Scientific Qualification (ASN) as Associate Professor in Organic Chemistry. Her current research aims to develop next-generation targeted therapeutics through integrated medicinal chemistry and translational drug discovery approaches.
Publications
Targeting the lipid membrane to prevent viral entry: the case of a C18-alkylated EGCG compound.
Minnelli C, Caucci S, Galeazzi R, Laudadio E, Romagnoli E, Frontini A, Rao L, Notarstefano V, Armeni T, Romaldi B, Menzo S, Mobbili G
Chem Biol Interact 2026 Feb;430():111971
FL30: an epidermal growth factor kinase inhibitor overcoming T790M and C797S mutations through unique conformational modulation mechanism.
Romagnoli E, Laudadio E, Mobbili G, Sorci L, Birarda G, Piccirilli F, Vaccari L, Vondracek H, Romaldi B, Marcaccio M, Storici P, Semrau M, Galeazzi R, Toma A, Aglieri V, Stipa P, Armeni T, Minnelli C
Int J Biol Macromol 2025 Aug;319(Pt 2):145453
Probing conformational dynamics of EGFR mutants via SEIRA spectroscopy: potential implications for tyrosine kinase inhibitor design.
Laudadio E, Piccirilli F, Vondracek H, Mobbili G, Semrau MS, Storici P, Galeazzi R, Romagnoli E, Sorci L, Toma A, Aglieri V, Birarda G, Minnelli C
Phys Chem Chem Phys 2024 Sep;26(35):22853-22857
Chemical Scaffolds for the Clinical Development of Mutant-Selective and Reversible Fourth-Generation EGFR-TKIs in NSCLC.
Laudadio E, Mangano L, Minnelli C
ACS Chem Biol 2024 Apr;19(4):839-854
Mechanistic insight toward EGFR activation induced by ATP: role of mutations and water in ATP binding patterns.
Laudadio E, Mobbili G, Sorci L, Galeazzi R, Minnelli C
J Biomol Struct Dyn 2023 ;41(14):6492-6501
Insights into PLGA-encapsulated epigallocatechin 3-gallate nanoparticles as a new potential biomedical system: A computational and experimental approach.
Minnelli C, Stipa P, Sabbatini S, Mengucci P, Mobbili G, Galeazzi R, Armeni T, Romaldi B, Celli A, Laudadio E
European Polymer Journal 2023, 182, 111723.
Identification of a novel nitroflavone-based scaffold for designing mutant-selective EGFR tyrosine kinase inhibitors targeting T790M and C797S resistance in advanced NSCLC.
Cristina M, Emiliano L, Leonardo S, Giulia S, Roberta G, Adolfo A, Marta SS, Paola S, Samuele R, Pierluigi S, Massimo M, Giovanna M
Bioorg Chem 2022 Dec;129():106219
Tuning curvature and phase behavior of monoolein bilayers by epigallocatechin-3-gallate: Structural insight and cytotoxicity.
Minnelli C, Moretti P, Laudadio E, Gerelli Y, Pigozzo A, Armeni T, Galeazzi R, Mariani P, Mobbili G
Colloids Surf B Biointerfaces 2022 Jan;209(Pt 1):112171
Influence of a lipophilic edaravone on physical state and activity of antioxidant liposomes: An experimental and in silico study.
Minnelli C, Laudadio E, Fiorini R, Galeazzi R, Armeni T, Stipa P, Rusciano D, Mobbili G
Colloids Surf B Biointerfaces 2022 Feb;210():112217
Selective induction of apoptosis in MCF7 cancer-cell by targeted liposomes functionalised with mannose-6-phosphate.
Minnelli C, Cianfruglia L, Laudadio E, Galeazzi R, Pisani M, Crucianelli E, Bizzaro D, Armeni T, Mobbili G
J Drug Target 2018 Mar;26(3):242-251