Lectures and seminars OnkPat Friday Seminar: Engineering exosomes for delivery of genome editors and RNA therapeutics

Host: Kasper Karlsson, Department of Oncology-Pathology

About Samir El Andaloussi

Samir EL Andaloussi is Professor of Biomolecular Medicine and Advanced Therapies at the Department of Laboratory Medicine, Karolinska Institutet. He is Principal Investigator for the Biomolecular Medicine lab and Head of Division for Biomolecular and Cellular Medicine within the department. He is also the Co-director of Research at the Karolinska ATMP Center. Prof Andaloussi is also a visiting Professor at University of Oxford. Additionally, he is also co-founder of, and scientific adviser for, Evox Therapeutics that develops engineered extracellular vesicles (EVs) for treatment of genetic diseases. Samir has worked on various aspects related to non-viral extrahepatic delivery of RNA and protein therapeutics, now with emphasis on the use engineered EVs and synthetic LNPs. He has recently established EV engineering methods that enable efficient targeted delivery of macromolecular therapeutics, such as gene editors and mRNAs in pre-clinical models with focus CNS and cancer. 

Selected publications

Efficient genome editing in the non-human primate brain using programmable extracellular vesicles
Liang, X., Zhou, H., Nizamudeen, Z. A., Kyriakopoulou, E., Evans, A. E., Roudi, S., Estupiñán, H. Y., Rädler, J., Hou, V. W. Q., Daniel, C. D.W., Hernandez-Perez, I., Singh, M., Parsi, P., Lonergan, D. A., Berlana, L. M., Walmsley, R., Chen, Y., Suermondt, J. S. M. T., Mowoe, M. O., Görgens, A., Smith, C. A., Redrup, G. O., Ashmore, L. D., Perez, S., Thapa, K. J., Banerjee, S., Bonner, S. E., Conceicao, M., Gavin, R. L., Hean, J., Horrocks, P. D., Levitin, M. O., Lundin, P., Sharma, H., Tawar, R. G., Liu, L., Gupta, D., Carter, D. R. F., Nordin, J. Z. and EL Andaloussi, S. . bioRxiv, 2026. 2026.08.05.741964. doi: 10.64898/2026.08.05.741964.

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors.
Liang X, Gupta D, Xie J, Van Wonterghem E, Van Hoecke L, Hean J, Niu Z, Ghaeidamini M, Wiklander OPB, Zheng W, Wiklander RJ, He R, Mamand DR, Bost J, Zhou G, Zhou H, Roudi S, Estupiñán HY, Rädler J, Zickler AM, Görgens A, Hou VWQ, Slovak R, Hagey DW, de Jong OG, Uy AG, Zong Y, Mäger I, Perez CM, Roberts TC, Carter D, Vader P, Esbjörner EK, de Fougerolles A, Wood MJA, Vandenbroucke RE, Nordin JZ, El Andaloussi S
Nat Commun 2025 Apr;16(1):4028

Antibody-displaying extracellular vesicles for targeted cancer therapy.
Wiklander OPB, Mamand DR, Mohammad DK, Zheng W, Jawad Wiklander R, Sych T, Zickler AM, Liang X, Sharma H, Lavado A, Bost J, Roudi S, Corso G, Lennaárd AJ, Abedi-Valugerdi M, Mäger I, Alici E, Sezgin E, Nordin JZ, Gupta D, Görgens A, El Andaloussi S
Nat Biomed Eng 2024 Nov;8(11):1453-1468

Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles.
Zickler AM, Liang X, Gupta D, Mamand DR, De Luca M, Corso G, Errichelli L, Hean J, Sen T, Elsharkasy OM, Kamei N, Niu Z, Zhou G, Zhou H, Roudi S, Wiklander OPB, Görgens A, Nordin JZ, Castilla-Llorente V, El Andaloussi S
Adv Sci (Weinh) 2024 Nov;11(42):e2407619