Lectures and seminars OnkPat Extra Seminar: Decoding the Cellular Language of Cancer-From Spatial Multi-Omics and AI to Actionable Tumor Ecosystems

Hosts: Arne Östman och Linglong Huang.

Bio

Linghua Wang, MD, PhD, is Professor in the Department of Genomic Medicine and Founding Executive Director of the Center for Cellular Language Intelligence at The University of Texas MD Anderson Cancer Center. She is also an Associate Member of the James P. Allison Institute and co-leads the focus area in Single-Cell Analytics and Spatial Multi-Omics within the Institute for Data Science in Oncology. Dr. Wang’s laboratory integrates artificial intelligence, computational genomics, digital pathology, single-cell and spatial multi-omics to decode how cells communicate, organize, and evolve within tumor ecosystems. 

Her research spans the transition from premalignancy to invasive cancer, primary tumor evolution and metastasis, minimal residual disease, and mechanisms of treatment response and resistance. Her laboratory develops computational and AI-driven methods, spatial atlases, predictive models, and translational biomarkers to advance precision and predictive oncology. 

Dr. Wang has authored more than 150 peer-reviewed publications with over 75,000 citations, including studies published in Nature, Science, Nature Medicine, Cancer Cell, Cancer Discovery, and Nature Genetics. She also serves on the Advisory Board of Cancer Cell and as a Scientific Editor for Cancer Discovery.

Selcted publications

A Spatial Atlas of Muscle-Invasive Bladder Cancer Reveals Lineage-Specific Vulnerabilities and Immune Architecture.
Yu K, Chen J, Chu YY, Nair S, Crupi E, Hasanov E, Mei Y, Han X, Liu Y, Liu Y, Pei G, Peng F, Liao J, Dai E, Chu T, Cho KS, Jiang J, Yan X, Dai Y, Wang J, Zhang B, Genovese G, Putluri N, Eberlin L, Yang L, Lin C, Kwong LN, Shamsutdinova D, Wani KM, Czerniak BA, Yu W, Zhao J, Guo CC, Hansel D, Pettaway C, Pisters L, Bree K, Navai N, Lee BH, Kamat AM, Sharma P, Corn P, Jiang CY, Shah AY, Alhalabi O, Msaouel P, Siefker-Radtke AO, Logothetis CJ, Campbell MT, Lazar AJ, Gao J, Wang L
Cancer Discov 2026 Oct;16(10):2037-2059

Multimodal spatial-omics reveal co-evolution of alveolar progenitors and proinflammatory niches in progression of lung precursor lesions.
Peng F, Sinjab A, Dai Y, Treekitkarnmongkol W, Yang S, Gomez Bolanos LI, Zhou T, Chen M, Serrano AG, Krishna A, Karimi N, Sharma M, Basi A, Pei G, Liao J, Liu Y, Feng J, Rahal Z, Liu Y, Jiang J, Yu K, Noun T, Liu Y, Khan K, Cho KS, Chen J, Solis LM, Mazzilli S, Dubinett S, Cascone T, Spira AE, Swisher S, Jimbo N, Hayashi T, Kishikawa S, Takamochi K, Itoh T, Yao T, Suzuki K, Kalhor N, Wistuba II, Li M, Moghaddam SJ, Fujimoto J, Burks J, Myers J, Akdemir K, Wang L, Kadara H
Cancer Cell 2026 Feb;44(2):321-339.e13

Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics.
Liu Y, Sinjab A, Min J, Han G, Paradiso F, Zhang Y, Wang R, Pei G, Dai Y, Liu Y, Cho KS, Dai E, Basi A, Burks JK, Rajapakshe KI, Chu Y, Jiang J, Zhang D, Yan X, Guerrero PA, Serrano A, Li M, Hwang TH, Futreal A, Ajani JA, Solis Soto LM, Jazaeri AA, Kadara H, Maitra A, Wang L
Cancer Cell 2025 May;43(5):905-924.e6

Molecular phenotypes and spatial archetypes: A new framework for cancer-associated fibroblasts.
Liu Y, Chen X, Dai Y, Jia Y, Kieffer Y, Xie L, Zhou Z, Tyler L, Kim AC, Biffi G, Krishnamurty AT, Mechta-Grigoriou F, Scherz-Shouval R, Sherman MH, Turley SJ, Wang L, Huang H
Cancer Cell 2026 Jul;44(7):1346-1367

Pan-cancer spatial atlas of tertiary lymphoid structures.
Cho KS, Liu Y, Pei G, Chen J, Dai Y, Liu Y, Zhou T, Bougouin A, Serrano A, Wani K, Jadhav A, Min J, Hernandez S, Lu W, Zhang D, Jiang J, Shamsutdinova D, Dai E, Peng F, Sinjab A, Guerrero PA, Julio ICL, Yu K, Clark H, Maru D, Li M, Futreal A, Lee S, Solis Soto LM, Shang L, Msaouel P, Ajani JA, Beird H, Jazaeri AA, Lazar AJ, Sautes-Fridman C, Fridman WH, Maitra A, Kadara H, Gao J, Sharma P, Wang L
Science 2026 May;392(6801):eadz2742

Spatial omics at the forefront: emerging technologies, analytical innovations, and clinical applications.
Liu Y, Dai Y, Wang L
Cancer Cell 2026 Jan;44(1):24-49

Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer.
Pei G, Min J, Rajapakshe KI, Branchi V, Liu Y, Selvanesan BC, Thege F, Sadeghian D, Zhang D, Cho KS, Chu Y, Dai E, Han G, Li M, Yee C, Takahashi K, Garg B, Tiriac H, Bernard V, Semaan A, Grem JL, Caffrey TC, Burks JK, Lowy AM, Aguirre AJ, Grandgenett PM, Hollingsworth MA, Guerrero PA, Wang L, Maitra A
Nature 2025 Jun;642(8066):212-221