Lectures and seminars Faculty event: Stephen Nash

Title 

Estimands framework for clinical trials

Abstract

The estimands framework was introduced by the European Medicines Agency (EMA) in 2020. The framework provides a structured way to align objectives, study design, and statistical analysis of randomised clinical trials. In particular, there is an emphasis on describing the relevant estimands in a transparent and structured way, and for thinking about strategies to handle what are called intercurrent events: things which happen after randomisation which affect the interpretability or availability of the final outcome measure. This talk will seek to explain the language used in the estimands framework, and how this relates to language used in causal modelling (of observational data).

About the speaker

Stephen Nash is a statistician in the Applied Biostatistics Group at MEB, who specialises in the design, conduct and analysis of randomised trials. He has particular experience in cancer trials and cluster-randomised trials, especially of complex interventions. He teaches an introduction to RCTs as part of the “Study Design & Analysis” course on the Biostatistics and Data Science MSc.

Faculty lunch

Join the faculty event in Wargentin! After the seminar, the faculty lunch will be served in Ljusgården. The faculty lunches are intended for employees at MEB, and a monthly net salary deduction of 260 SEK will be made for those who work here 20% or more. If you have any questions about the lunch or specific dietary needs due to allergies, etc., please contact internservice@meb.ki.se. If you won’t be participating in the lunches for all or part of the spring term, our new routine is that you need to contact hr-support@meb.ki.se at the start of a new term, to be removed from the list. Retroactive adjustments will not be possible.  

Please, check the labeling on the salads not to take special diet foods that were pre-ordered by your colleagues.