Lectures and seminars CCK-lecture with MGI and KI-China faculty: Cell Fate Control at the Chromatin Level
Speaker: Duanqing Pei
Ph.D. Chair Professor of Regenerative Biology, Westlake University, Hangzhou China Centre Director (Academic), Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Chinese Academy of Sciences, Hong Kong SAR China
Host: Rickard Sandberg, CMB and XpressGenomics, MGI and CCK
Abstract: Evidence from various models of cell fate programming and reprogramming supports the hypothesis that a common machinery controls all cell fate decisions. We have proposed a “open-close and close to open or OCCO” working model for this machine at the chromatin level. Current effort focus on further identifying components of this machine that impact 3D genome organization during transitions between Toti-, naive and primed potencies in preimplantation embryo. The resulting insights have inspired us to design artificial cell fate regulators that work on the cell fate machinery.
CV
Chair Professor of Regenerative Biology, Associate Vice President,
Dean of the School of Future Biomedicine, Westlake University, Hangzhou China
Centre Director (Academic),Centre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation, Chinese Academy of Sciences, Hong Kong SAR China
Previous academic positions held:
1991 – 2020 Postdoc, Dept Internal Med, Univ Michigan, USA. Res.Investigator, Dept Int.Med, Univ. Michigan, USA. Assist./Assoc.Prof (Tenured),
Dept Pharmcology, UMN, USA. Prof of Pharmacology, Tsinghua Univ. China.
Professor and Deputy Director General (2004) and Director General (2008-), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Co-Director, Max Planck – GIBH Joint Center for Regenerative Biomedicine
Academic qualifications:
1980 – 1984 B. A, Huazhong Agricultural College. 1985 – 1991 Ph.D. University of Pennsylvania, USA
Seleced publications:
Chen J, Pei D. Reprogramming in suspension. Nat Methods. 2012 Apr 27;9(5):449-51
Esteban MA, Pei D. Vitamin C improves the quality of somatic cell reprogramming. Nat Genet. 2012 Mar 28;44(4):366-7.
ChenJ.,LiuH.,LiuJ.,QiJ.,WeiB.,YangJ,LiangH.,ChenY,ChenJ,WuY,GuoL, ZhuJ, Peng T., Zhang Y., Chen S, Li X, Li D, Wang,T, Pei, D. H3K9 Methylation is a barrier during somatic cell reprogramming into iPSCs. Nature Genetics, 2013. 45: 34-42.
Wang L., Wang L., Huang W, Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., Wu W., So K.F., Pan G. , Pei D., Generation of integration-free neural progenitor