What's the mechanism of action for ketamine in treatment of depression?

Ketamine has very rapid onset in treatment of depression. However, it has also other effects that may limit it from making a big difference for the burden of disease caused by depression world wide. In a molecular imaging study performed by Johan Lundbergs group the mechanism of action of ketamine in depressed patients, in order to pave the way for other, even better treatment options.

You can read more about depression here: https://ki.se/en/research/spotlight-on-treatment-for-depression