Published: 22-06-2020 15:56 | Updated: 22-06-2020 16:11

The regulation of glycemia after stroke improves neurological recovery in diabetes

Vladimer Darsalia and Cesare Patrone
Vladimer Darsalia och Cesare Patrone

In a study in mice, researchers at Karolinska Institutet have discovered a new potential therapeutic approach to facilitate neurological recovery in people with diabetes suffering from stroke. The treatment strategy is based on the chronic normalization of hyperglycemia after stroke. The scientists hope that these new results, presented in the scientific journal Diabetes, open the possibility to improve the current rehabilitative strategies against stroke in the diabetic population.

The prevalence of diabetes in the world is expected to rise dramatically to 700 million people in 2045. Stroke is one of the major complications in people with diabetes who are not only at higher risk to suffer from stroke but also have diminished and slower recovery in the rehabilitation phase. While life style changes have in part reduced the risk to have a stroke, there are no specific therapies to improve neurological recovery after stroke in people with diabetes.

Glycaemia regulation

The results show the efficacy of two unrelated diabetes treatments that normalize hyperglycemia, Linagliptin and Glimepiride in facilitating neurological recovery after stroke. The initiation of glycemia regulation could even start several days after stroke and still show positive results.

- This in turn suggests that people with diabetes might have a better prognosis after a stroke if the chronic regulation of glycemia will be given a high priority after hospitalization, says Cesare Patrone  who led the study with Vladimer Darsalia.

The current study is the result of a collaborative effort between the NeuroCardioMetabol Group at the Department of Clinical Science and Education, Södersjukhuset, the Internal Medicine Unit at Södersjukhuset and Boehringer Ingelheim Pharma GmbH & Co.

Funders of the study were The Swedish Research Council, Diabetesfonden, EFSD, STROKE-Riksförbundet, O. E. och Edla Johanssons vet. Stiftelse, Konung Gustaf V:s & Drottning Victorias Frimurarestiftelse, ALF and the Swedish Heart-Lung foundation.


The Regulation of Glycemia in the Recovery Phase After Stroke Counteracts the Detrimental Effect of Obesity-Induced Type 2 Diabetes on Neurological Recovery.
Augestad IL, Pintana H, Larsson M, Krizhanovskii C, Nyström T, Klein T, Darsalia V, Patrone C. Diabetes 2020 Jun;():


Cesare Patrone Senior Lecturer/Clinical Position