New publication about subset of blood forming stem cells has been published in Nature
Sten Eirik Jacobsen Professor at Center for Hematology and Regenerative Medicine is one of the authors and writes:
“Carrelha et al have identified a new subset of blood forming stem cells, who, despite sharing the ability of other blood forming stem cells to produce all blood cell lineages, is fully dedicated to exclusively produce blood platelets, whose function is to stop bleeding. Identification of these platelet-restricted stem cells opens up new opportunities to overcome life-threatening platelet loss frequently accompanying treatment with cancer chemotherapy. In addition they demonstrate that a limited number of other blood forming stem cell subsets exist, each with a distinct and stable propensity to exclusively produce a restricted repertoire of blood cell lineages.”
The publication Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells has been published in Nature (2018) Online 3 January.
Read the abstract
Carrelha J, Meng Y, Kettyle LM, Luis TC, Norfo R, Alcolea V, Grasso F, Gambardella A, Grover A, Högstrand K, Lord AM, Sanjuan-Pla A, Woll PS, Nerlov C, Jacobsen SEW