Lectures and seminars OnkPat Friday Seminar: Decoding cellular circuits in intestinal regeneration and tumorigenesis
Welcome to OnkPat Friday Seminar with Eduardo Villablanca, Department of Medicine, Solna.
Host: Kasper Karlsson, Department of Oncology-Pathology.
Selected references
Liver X receptor unlinks intestinal regeneration and tumorigenesis.
Das S, Parigi SM, Luo X, Fransson J, Kern BC, Okhovat A, Diaz OE, Sorini C, Czarnewski P, Webb AT, Morales RA, Lebon S, Monasterio G, Castillo F, Tripathi KP, He N, Pelczar P, Schaltenberg N, De la Fuente M, López-Köstner F, Nylén S, Larsen HL, Kuiper R, Antonson P, Hermoso MA, Huber S, Biton M, Scharaw S, Gustafsson JÅ, Katajisto P, Villablanca EJ
Nature 2025 Jan;637(8048):1198-1206
B cell expansion hinders the stroma-epithelium regenerative cross talk during mucosal healing.
Frede A, Czarnewski P, Monasterio G, Tripathi KP, Bejarano DA, Ramirez Flores RO, Sorini C, Larsson L, Luo X, Geerlings L, Novella-Rausell C, Zagami C, Kuiper R, Morales RA, Castillo F, Hunt M, Mariano LL, Hu YOO, Engblom C, Lennon-Duménil AM, Mittenzwei R, Westendorf AM, Hövelmeyer N, Lundeberg J, Saez-Rodriguez J, Schlitzer A, Das S, Villablanca EJ
Immunity 2022 Dec;55(12):2336-2351.e12
The spatial transcriptomic landscape of the healing mouse intestine following damage.
Parigi SM, Larsson L, Das S, Ramirez Flores RO, Frede A, Tripathi KP, Diaz OE, Selin K, Morales RA, Luo X, Monasterio G, Engblom C, Gagliani N, Saez-Rodriguez J, Lundeberg J, Villablanca EJ
Nat Commun 2022 Feb;13(1):828
Biography
Dr. Villablanca, initially a developmental biologist specializing in cell migration using zebrafish, transitioned to immunology during his doctoral studies in Milan. Focused on intestinal leukocyte trafficking, he trained at Harvard Medical School (HMS) as Mucosal Immunologist under the supervision of Dr. Rodrigo Mora. Later became an Instructor in Medicine (HMS) in Ramnik Xavier’s lab where he investigated Inflammatory Bowel Disease risk genes. In 2014, he established his own laboratory at Karolinska Institute, Sweden, blending systems immunology, developmental biology, and mucosal immunology. His research centers on understanding mechanisms maintaining intestinal homeostasis and the implications of their failure in disease, such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC).
Visit the Villablanca lab webpage.