Lectures and seminars OnkPat Extra Seminar: Engineering scFv-Peptide Conjugates and Functionalized Lipid Nanoparticles for Targeted Synthetic Oligonucleotide/Peptide Drug Delivery and In Vivo CAR Cell Generation

Värd: Kasper Karlsson, Department of Oncology-Pathology

About Sara Mangsbo

Dr. Sara Mangsbo is a professor/academic research lead in biologics, alongside entrepreneur based at Uppsala University (UU), where she leads a research group focused on immunology and cancer therapeutics. She is also the new vice dean of collaboration for the area of medicine and pharmacy at UU. 

She brings a combination of expertise in immunotherapy, delivery technology, and translational leadership. Her research spans the development of agonistic and bispecific antibodies, as well as the invention of the ADAC technology for adaptable antibody-based delivery of synthetic peptides and neoantigens. 

Beyond academia, Dr. Mangsbo has extensive entrepreneurial experience, having co-founded Immuneed AB as well as Strike Pharma AB and successfully been part of taking investigational drugs, such as mitazalimab and TENDU101, from research into clinical trials.

Selected publications

Tommy Lidström, Alexandros Kostakis, Rosanne Veerman, Venera Emruli, Safia Guleed, Tina Furebring, Jonas A. Nilsson, Sara Mangsbo; Abstract 3010: LIN-T (lipid integrated tag): An optimized tag-lipid nanoparticle design for targeted therapeutic mRNA delivery. Cancer Res 1 April 2026; 86 (7_Supplement): 3010. 

Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange.
Laurén I, Kostakis A, Lord M, Björklund E, Wang X, Tari PS, Veerman RE, Saleh A, Mebrahtu A, Rockberg J, Dönnes P, Andersson O, Persson H, Juriga D, Hansson P, Mangsbo S
Int J Biol Macromol 2026 Mar;352():151135

A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice.
Mebrahtu A, Laurén I, Veerman R, Akpinar GG, Lord M, Kostakis A, Astorga-Wells J, Dahllund L, Olsson A, Andersson O, Persson J, Persson H, Dönnes P, Rockberg J, Mangsbo S
Nat Commun 2024 Nov;15(1):9542