Lectures and seminars Neurochemical contextualization of cortical neurophysiological changes in Parkinson's disease
Daniel Lundqvist's research group at the Department of Clinical Neurosience welcomes you to a lecture with focus on MEG, brain imaging and Parkinson's disease, with neuroscientist Alex Wiesman.
Title: Neurochemical contextualization of cortical neurophysiological changes in Parkinson's disease
Lecturer: Alex Wiesman, Assistant Professor - Biomedical Physiology & Kinesiology, Simon Fraser University, Canada. Scientific Director - ImageTech Lab Core Facility.
Abstract: A recent line of our research uses multimodal brain imaging and normative atlases of cortical neurochemistry to examine the interrelationships between catecholamine system topographies, neurophysiological function, and clinical variability in patients with Parkinson's disease. In this talk, we will cover two of these recent studies, demonstrating (1) a link between noradrenergic dysfunction, cortical alpha rhythms, and cognitive impairments and (2) off-target cortical effects of dopamine replacement therapies, which are associated with diminished clinical response across patients with Parkinson's disease. These findings may lead to new markers for disease tracking and therapeutics in patients with Parkinson's disease, and form the basis for emerging lines of inquiry in my new Neurophysiology of Aging and Neurodegeneration Laboratory in Vancouver.