Conferences and symposiums Mini-symposium: Decoding and targeting glioblastoma
The Ulf von Eluer Lectureship Foundation warmly invites you to a mini-symposium on "Decoding and targeting glioblastoma", with Prof. Wendell Lim and Prof. Sten Linnarsson
Wendell Lim (University of California, San Francisco) is a pioneer in synthetic cell biology, developing approaches to reprogram cellular signalling and engineer immune cells with programmable therapeutic functions. His laboratory is applying these principles to glioblastoma, engineering T cells that can recognize the brain tumour microenvironment to improve the specificity and persistence of glioblastoma-targeted T-cell therapies.
Simic MS, Watchmaker PB, Gupta S, Wang Y, Sagan SA, Duecker J, Shepherd C, Diebold D, Pineo-Cavanaugh P, Haegelin J, Zhu R, Ng B, Yu W, Tonai Y, Cardarelli L, Reddy NR, Sidhu SS, Troyanskaya O, Hauser SL, Wilson MR, Zamvil SS, Okada H, Lim WA. Programming tissue-sensing T cells that deliver therapies to the brain. Science. 2024;386(6726). doi:10.1126/science.adl4237.
Choe JH, Watchmaker PB, Simic MS, Gilbert RD, Li AW, Krasnow NA, Downey KM, Yu W, Carrera DA, Celli A, Cho J, Briones JD, Duecker JM, Goretsky YE, Dannenfelser R, Cardarelli L, Troyanskaya O, Sidhu SS, Roybal KT, Okada H, Lim WA. SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Science Translational Medicine. 2021;13(591). doi:10.1126/scitranslmed.abe7378.
Sten Linnarsson (Department of Medical Biochemistry and Biophysics, Karolinska Institutet) is a pioneer in single-cell transcriptomics, developing methods to map cell types and states across the developing and adult brain. His laboratory is applying these approaches to glioblastoma to uncover how tumour cells interact with their surrounding tissue and how their molecular states and spatial organization can reveal new therapeutic opportunities.
Mossi Albiach A, Janusauskas J, Jacobsen JK, Kapustová I, Karamzadeh R, Kvedaraite E, Hu L, Franck MCM, Ramal García M, Fernández-García D, Mannens C, Codeluppi S, Munting JB, Borm LE, Shamikh A, Lönnerberg P, Siletti K, Persson O, Linnarsson S. Tissue-reactive zonation of mesenchymal-like phenotypes in human glioblastoma. Med. 2026;7(8):101228. doi:10.1016/j.medj.2026.101228.
Vinsland E, Marco Salas S, Kapustová I, Hu L, Webb S, Li X, He X, Nilsson M, Haniffa M, Barker RA, Persson O, Raleigh DR, Sundström E, Lönnerberg P, Linnarsson S. Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas. Nature Cell Biology. 2026. doi:10.1038/s41556-026-02074-9.
"Smarter cell therapies for brain cancer", Wendell Lim
"Towards novel therapy for glioblastoma", Sten Linnarsson
Fika
Contact: Ana Teixeira (ana.teixeira@ki.se)