Lectures and seminars Guest seminar - Prof. Andrei Thomas-Tikhonenko, University of Pennsylvania
Title: “Alternatively spliced tumor epitopes, lost and found”.
On June 24 at 10:30 in room Ragnar Granit, Biomedicum.
Welcome to guest seminar by Dr. Andrei Thomas-Tikhonenko
Professor of Pathology & Laboratory Medicine at the University of Pennsylvania and Principal Inves;gator at the Children’s Hospital of Philadelphia (CHOP), USA.
Dr. Thomas-Tikhonenko is a leading cancer biologist with over 25 years of continuous NIH funding. His research focuses on MYC-driven mechanisms in solid and hematopoietic malignancies, particularly lymphomas and leukemias, with a strong emphasis on microRNAs and mRNA splicing. His work has been published in premier journals such as Nature Genetics, Cancer Discovery, and JCI. At CHOP, he plays a key role in the Center for Childhood Cancer Research and has led several major translational initiatives, including his involvement in the SU2C-St. Baldrick’s Pediatric Cancer Dream Team (recipient of the 2021 AACR Team Science Award) and the Beau Biden Cancer Moonshot Initiative.
Select Publications
Neuronal cell adhesion molecule (NRCAM) variant defined by microexon skipping is an essential, antigenically distinct, and targetable proteoform in high-grade glioma.
Sehgal P, Naqvi AS, Higgins M, Liu J, Harvey K, Jarroux J, Kim T, Mankaliye B, Mishra P, Watterson G, Fine J, Davis J, Hayer KE, Castro A, Mogbo A, Drummer C, Martinez D, Koptyra MP, Ang Z, Wang K, Farrel A, Quesnel-Vallieres M, Barash Y, Spangler JB, Rokita JL, Resnick AC, Tilgner HU, DeRaedt T, Powell DJ, Thomas-Tikhonenko A
bioRxiv 2025 Jan;():
An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia.
Torres-Diz M, Reglero C, Falkenstein CD, Castro A, Hayer KE, Radens CM, Quesnel-Vallières M, Ang Z, Sehgal P, Li MM, Barash Y, Tasian SK, Ferrando A, Thomas-Tikhonenko A
bioRxiv 2024 Jul;():
Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies.
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Torres Diz M, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Asnani M, King Sainos P, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A
Blood 2023 Nov;142(20):1724-1739
Discovery of antibodies targeting multipass transmembrane proteins using a suspension cell-based evolutionary approach.
Krohl PJ, Fine J, Yang H, VanDyke D, Ang Z, Kim KB, Thomas-Tikhonenko A, Spangler JB
Cell Rep Methods 2023 Mar;3(3):100429
Modulation of CD22 Protein Expression in Childhood Leukemia by Pervasive Splicing Aberrations: Implications for CD22-Directed Immunotherapies.
Zheng S, Gillespie E, Naqvi AS, Hayer KE, Ang Z, Torres-Diz M, Quesnel-Vallières M, Hottman DA, Bagashev A, Chukinas J, Schmidt C, Asnani M, Shraim R, Taylor DM, Rheingold SR, O'Brien MM, Singh N, Lynch KW, Ruella M, Barash Y, Tasian SK, Thomas-Tikhonenko A
Blood Cancer Discov 2022 Mar;3(2):103-115