Lectures and seminars Bergström & Samuelsson-MBB keynote lecture with Geert Kops
Welcome to a lecture with Geert Kops, Director of the Hubrecht Institute, Investigator at Oncode Institute, and professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht, The Netherlands. His group is interested in the processes that ensure correct chromosome segregation during cell division.
Speaker
Geert Kops is Director of the Hubrecht Institute, Investigator at Oncode Institute and professor of Molecular Tumor Cell Biology at the University Medical Center Utrecht, The Netherlands. His group is interested in the processes that ensure correct chromosome segregation during cell division. Errors in chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors. The Kops laboratory employs advanced technologies such as super-resolution and live-cell microscopy, single-cell DNA sequencing, and high-throughput genomic profiling to uncover fundamental mechanisms that preserve genome stability and promote cancer development.
Key publications
Sacristan C, Samejima K, et al. Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin. Cell (2024) 10.1016/j.cell.2024.04.014
Klaasen, S.J., Truong, M.A., van Jaarsveld, R.H. et al. Nuclear chromosome locations dictate segregation error frequencies. Nature (2022). 10.1038/s41586-022-04938-0
Bolhaqueiro ACF, Ponsioen B et al. Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids. Nat Genet. (2019) 10.1038/s41588-019-0399-6
Contact
Bennie Lemmens Bennie.Lemmens@ki.se
Bjørt K. Kragesteen Bjort.Kragesteen@ki.se
Christoph Ziegenhain Christoph.Ziegenhain@ki.se
Bergström & Samuelsson - MBB keynote lectures
We are thrilled to announce a new lecture series celebrating the groundbreaking contributions of MBB’s Nobel Prize winners in Physiology or Medicine in 1982 Sune Bergström and Bengt Samuelsson for their pioneering work on prostaglandins*. This series will feature top speakers from around the world, sharing their latest research and insights in the broad research areas of MBB. The Bergström & Samuelsson MBB keynote lectures will take place at the Nobel Forum and are followed by a mingle with champagne! PhDs and postdocs can sign up for the lunch together with the speaker (12:00-13:15).
*Bergström purified and determined the chemical structure of several prostaglandins, while Samuelsson detailed their formation from fatty acids, particularly arachidonic acid. Their work led to the discovery of important components in the prostaglandin system, including leukotrienes and thromboxanes, which play crucial roles in inflammation, blood clotting, and various other bodily functions. These findings provided essential knowledge about normal body functions and explained mechanisms behind diseases such as allergies, inflammations, and vascular diseases. As a result, their research opened up new avenues for medical treatments, leading to the development of drugs for conditions like asthma and contributing to advancements in reproductive medicine.