Asthma increases risk of complications during pregnancy and delivery

Women with asthma suffer more often from preeclampsia (PE) and run a higher risk of giving birth to underweight babies. These and other complications during pregnancy and delivery can not be explained by hereditary or environmental factors, according to a study from Karolinska Institutet published in The Journal of Allergy and Clinical Immunology: In Practice.

Asthma is a common disease caused by chronic inflammation in the lungs with symptoms of coughing and breathlessness, and affects between 8-10 percent of women of childbearing age in Sweden.

Using data from the Swedish birth, prescribed drug and patient registers, researchers at Karolinska Institutet have been able to examine the link between asthma in pregnant women and pregnancy/delivery outcomes. Studying more than 1 million births to just over 700,000 women between 2001 and 2013, they found that 10 percent of the babies born had a mother with asthma.

“Four percent of all pregnant women develop preeclampsia. We found that the risk of preeclampsia is 17 percent higher in women with asthma compared to women without asthma”, says the study’s lead author Dr Gustaf Rejnö, obstetrician and doctoral student at Karolinska Institutet’s Department of Medical Epidemiology and Biostatistics.

Additionally, women with asthma were more likely to have underweight babies, instrumental deliveries, caesarean sections and shorter pregnancies.

Studied the women’s cousins and sisters

To ascertain whether the complications could be attributed to hereditary or environmental factors, the researchers also identified the women’s asthma-free cousins and sisters who had given birth during the same period. On comparing the groups they found that the correlations between maternal asthma and complications during pregnancy and delivery held.

“It seems to be the asthma per se that causes these complications,” says Dr Rejnö. “This means that well-controlled asthma during pregnancy could reduce the relative incidence of complications during pregnancy and childbirth. In an earlier study we saw that this was indeed the case.”

The study was financed by the Swedish Research Council, Stockholm County Council, FORTE, the Strategic research programme in Epidemiology and the Swedish Heart and Lung Foundation.

Publication

”Adverse Pregnancy Outcomes in Asthmatic Women: A Population-Based Family Design Study”
Gustaf Rejnö, Cecilia Lundholm, Kjell Larsson, Henrik Larsson, Paul Lichtenstein, Brian D’Onofrio, Sissel Saltvedt, Catarina Almqvist
Journal of Allergy and Clinical Immunology: In Practice, online 4 October 2017, doi: 10.1016/j.jaip.2017.07.036