Oxysterols guide gut immune cells and are involved in inflammatory bowel disease
KI Press Office announces: "Researchers at Karolinska Institutet report that cholesterol metabolites cause specific immune cells in the large intestine to move, which lies behind the formation of the immune system's important lymphoid tissue in the intestine. The study, published in the journal Immunity, paves the way for a new possible treatment for patients with inflammatory bowel disease."
Tim Willinger, researcher at Center for Infectious Medicine, is the leader of this study.
”Oxysterol sensing through the receptor GPR183 promotes the lymphoid tissue-inducing function of innate lymphoid cells and colonic inflammation”
Johanna Emgård, Hana Kammoun, Bethania García-Cassani, Julie Chesné, Sara M. Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R. Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J. Villablanca, Henrique Veiga-Fernandes, João P. Pereira, Richard A. Flavell, Tim Willinger
Immunity, online 16 January 2018