New thesis on thrombosis
Linda Labberton at the research group Clinical Chemistry and Blood Coagulation will defend her thesis "Mechanisms and regulation of the polyphosphate/factor XII-driven contact system in thrombosis and hemostasis" on October 28, 2016. Main Supervisor is Professor Thomas Renné.
What's the main focus of your thesis?
Blood coagulation is essential to prevent loss of blood, but can also contribute to occlusion of vessels (thrombosis). Thrombosis is the most common cause of death in the developed world. In my thesis I looked into the mechanisms and regulation of the polyphosphate/FXII-driven contact system in thrombosis.
Which are the most important results?
We developed recombinant proteins to target the inorganic polymer polyphosphate, which leads to protection from thrombosis without bleeding as a side effect in in vivo models.
How can this new knowledge contribute to the improvement of people's health?
Current anticoagulation therapy for prevention or treatment of thrombosis is sufficient, however results in an increase in potentially life threatening bleedings. By using the techniques and proteins I developed during my thesis a new strategy of preventing thrombosis can be developed without having bleedings as a side effect.
Dissertation seminar
October 28, 2016 at 09:00, venue: CMM Lecture Hall L8:00, more information in the calendar
Thesis
Manuscript
Neutralizing blood-borne polyphosphatein vivo provides safe thromboprotection
Labberton et al., Nat Commun. 2016 Sep 6;7:12616. doi: 10.1038/ncomms12616