Lectures and seminars External MBB Seminar: David Walt "Ultrasensitive Protein Measurements for Fundamental Biochemistry and Clinical Applications"
Seminar with David R. Walt, Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard Medical School, Department of Pathology, Brigham and Women’s Hospital.
We have developed microwell arrays as a platform for studying both fundamental biochemistry and performing clinical measurements. The microwells can be used as miniature reaction chambers to measure the kinetics of large numbers of individual enzyme molecules and observe phenomena that cannot be seen using bulk techniques. The arrays can also be used to measure the concentrations of proteins and nucleic acids more than a thousand times lower than traditional assays. This ultrasensitivity provides the ability to measure molecules in biological samples, such as blood, at levels that cannot be detected using conventional methods.
About the speaker
David R. Walt is the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard Medical School and Professor of Pathology at Harvard Medical School and Brigham and Women’s Hospital, is a Core Faculty Member of the Wyss Institute at Harvard University and is a Howard Hughes Medical Institute Professor. Previously, he was University Professor at Tufts University. His laboratory pioneered the development of microwell arrays, which revolutionized the field of genetic analysis. Dr. Walt’s laboratory also introduced the idea of digital protein detection by developing a high throughput technology for performing single molecule analysis. Dr. Walt is the Scientific Founder of Illumina Inc., Quanterix Corp., and has co-founded several other life sciences startups including Ultivue, Inc., Arbor Biotechnologies, Sherlock Biosciences, and Vizgen, Inc. He has received numerous national and international awards and honors for his fundamental and applied work in the field of optical microwell arrays and single molecules. He is a member of the National Academy of Engineering, the National Academy of Medicine, a Fellow of the American Academy of Arts and Sciences, a Fellow of the American Institute for Medical and Biological Engineering, a Fellow of the National Academy of Inventors, and is inducted in the US National Inventors Hall of Fame.