Published: 29-05-2018 11:21 | Updated: 19-02-2020 13:22

Dissertation 15 June 2018: Xu Chen

On Friday June 15, Xu Chen will defend his thesis "Genetic epidemiology of cardiometabolic biomarkers : twin studies in the genomic era". His opponent will be Dr Kerrin Small from the Department of Twin Research and Genetic Epidemiology, King's College London. Xu's supervisors are Patrik Magnusson, Nancy Pedersen, Sara Hägg, Johan Frostegård and Per Svensson.

Xu's thesis includes four studies with the aim to answer four genetic epidemiological questions for cardiometabolic biomarkers/ traits, by using classical twin studies and novel genomic methods. To summarize, Xu's thesis quantified the proportion of genetic contributions to the variation (study I) and covariation (study II) for 24 traditional cardiometabolic biomarkers/traits; it identified the genetic variants (common SNPs) associated with novel biomarker IgM anti-PC (study III); it also tested whether polygenic evidence supports the association and causality between blood lipids and ALS (study IV).

Time and location: 09:00, June 15 2018 in the lecture hall Petrén, Nobels väg 12B, Karolinska Institutet, Solna