Published: 2021-11-11 13:13 | Updated: 2021-11-11 13:18

Campus Flemingsberg first in Europe with new equipment for imaging technology (Momentum MPI)

The Preclinical Imaging Facility (PIF) at the Department of Laboratory Medicine has been the first center in Europe to install new equipment for modern imaging technology: Magnetic Particle Imaging (MPI; Momentum) at Campus Flemingsberg.

– It is very exciting that the first MPI instrument is placed at Campus South. It will certainly strengthen the collaboration between different research groups and the university hospital and hence, the translational and clinical-based research. We hope MPI technology will benefit patients’ health in the future.

Moustapha Hassan, Department of Laboratory Medicine.

Photo of Momentum Magnetic Particle Imaging (MPI) together with the crew of responsible: Ashley Truxal, Moustapha Hassan, Matt Newgren, Ying Zhao, Sandra Oerther.
Momentum Magnetic Particle Imaging (MPI). Från vänster: Ashley Truxal, Moustapha Hassan, Matt Newgren, Ying Zhao, Sandra Oerther. Foto: Rui He

Magnetic particle imaging (MPI) has been the most promising imaging technology during the past 20 years and is expected to change the landscape of modern medical imaging in translational research.

MPI technology is a more sensitive imaging technology compared to other imaging techniques. MPI only detects particles without being disturbed by organs nearby. The technology uses superparamagnetic iron oxide nanoparticles (SPIO) which are an approved contrast agent for magnetic resonance imaging (MRI) usage. SPIO is eliminated naturally through the immune system, ie immune cells transport the nanoparticles of iron oxide to the liver where they are metabolized.

Today MPI technology is used in several research areas, such as:

  • Stem cell research and immunotherapy, where the migration of cells is followed.
  • Arthritis and atherosclerosis, a clearer picture of inflammation and plaque formation can be investigated.
  • Tumor imaging, where the formation of new blood vessels (angiogenesis) in the tumor can be studied.

MPI technology has several application areas including clinical diagnostics, e.g. in blood pool imaging, cardiovascular disease, cancer, cell tracking and functional brain imaging.

MPI was purchased through grants from CIMED (The Center for Medical Innovation).

History

MPI was first reported in 2001 (Philips Research lab in Hamburg). The first system was established and reported in 2005. The first commercial MPI scanners have recently become available from Magnetic Insight (Momentum) and Bruker. In 2019, the first article on MPI instrument for imaging the human brain was published in Nature Communications. See link below.