Lectures and seminars What is life? Exploring the human building-blocks of life
Speaker: Mathias Uhlén, Science for Life Laboratory, Karolinska Institutet and Royal Institute of Technology
Host: Ingemar Ernberg
The Human Protein Atlas (HPA) is an international program with the aim to map of all the human proteins in cells, tissues and organs using integration of various omics technologies, including AI-based systems biology. The current version (www.proteinatlas.org) consists of six separate parts with more than 10 million bioimages each focusing on a particular aspect of the genome-wide analysis of the human proteins. All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. The implications for the understanding of human biology in health and disease will be discussed with a focus on the development of pharmaceutical drugs based on data-driven life science.
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Selected publications from the last years as senior author:
- Uhlen et al (2015) “Tissue-based map of the human proteome” Science 347(6220):1260419.
- Uhlen et al (2017) “A pathology atlas of the human cancer transcriptome” Science 357(6352): eaan2507
- Uhlen et al (2019 “A genome-wide transcriptomic analysis of protein-coding genes in human blood cells” Science 366 (6472): eann9198
- Uhlén et al (2019) ”The human secretome.” Science Signal. 12(609): eaaz0274
- Sjöstedt et al (2020) “An atlas of the human, pig and mouse brain” Science 367 eaay5947