Lectures and seminars Webinar: Zebrafish as a model for basic and translational cancer studies

Speaker

Dr. Jensen participated in establishing the first zebrafish tumor xenograft models approximately 18 years ago and is today one of the leading experts in this methodology and the use of zebrafish tumor models within cancer research and precision medicine.

He currently operates as the PI of the zebrafish laboratory at Linköping University and is also involved in the spin-off company BioReperia that develops zebrafish patient-derived tumor models for precision medicine within oncology.

Registration

Register here (by October 3, 12.00 CEST)

Abstract

Zebrafish cancer models have recently emerged as powerful systems for understanding key aspects of cancer biology such as mechanisms underlying treatment resistance, invation/metastasis and immune-oncology.

Many spontaneous tumor models are currently available through the international resource centers, and methodology for establishing cell line-derived or patient-derived xenograft models have been thoroughly elaborated and implemented at many zebrafish facilities (including at KI).

The main benefits include the ease of visualization in living, tumor-baring larvae allowing observations in real time and single cell-resolution, the speed of the models (days) compared to e.g. rodent models (weeks or months), and the ease of generating hundreds of tumor-baring larvae per day thereby facilitating compound or tumor library screenings.lfare outcomes. Measures included both classic tests of anxiety-like behavior as well as stress-related physiology in combination with novel measures such as intra-cage ultrasonic vocalizations.

Both behavioral and physiological markers were affected by interventions, suggesting that environmental variables influence study outcomes. It is therefore critical that environmental parameters be considered in study design and post-study reporting.

Contact

E-mail: las-edu@km.ki.se