Lectures and seminars Webinar: Humanized mice - their concept, generation, use, strengths and limitations
The aim of these CPD webinars (Continuing professional development) is to follow the legal requirements for maintenance and demonstration of competence in laboratory animal science, and to facilitate the implementations of the 3R’s in routine animal work.
Speaker
Dr. Ditte Olsen received her Master of Science in Molecular Biology from Aarhus University, Denmark and earned her industrial PhD in Neuroscience from Aarhus University and Lundbeck. During her PhD, Ditte studied the dopaminergic system in various transgenic animal models. During her postdoctoral training, her focus changed to the field of cardiovascular disorders.
Following her postdoctoral training, she joined a biotech company where her focus was on preclinical research using small molecules to reduce high cholesterol levels. Ditte brings nearly 15 years of in vivo research experience to her role as a Field Application Scientist at Taconic.
Register here (by October 15, 12.00 CEST)
Abstract
Immunodeficient mice have been integral tools for preclinical research and drug development for many years. These mice have been classically used when human cells and/or tissues are required. The applications are broad, ranging from safety assessment, infectious disease, oncology and immuno-oncology to autoimmune disease and much more.
Several different super-immunodeficient mouse strains have been developed such as the NOG and NSG strains. These mice lack mature T, B, and NK cells allowing for increasingly more advanced humanization including human immune system and engraftment with difficult human cell lines and patient derived tumors (PDX).
The humanization can be done with peripheral blood mononuclear cells PBMCs, which are differentiated mature cells from adult donors, hematopoietic stem cells (HSCs) or more specific cell populations such as NK cells.
Contact
E-mail: las-edu@km.ki.se