Lectures and seminars (Super-) selective biomaterials: a balancing act of rigidity and geometry at the nanoscale” with Dr Maartje Bastings, EPFL

22-03-2024 3:00 pm Add to iCal
Campus Solna Peter Reichard, Biomedicum, Solna

Dr. Maartje Bastings leads the Programmable Biomaterials Laboratory at the at the École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

The Programmable Biomaterials Laboratory develops DNA origami-based materials as an engineering tool to explore the importance of structural mechanics, valency and spatial organization on the functions of membrane proteins. Using these tools, Dr. Bastings has made significant contributions to the study of the mechanisms of cell-cell communication, with a focus on the immune system. In particular, Dr. Bastings has elucidated the functional implications of the nanoscale spatial organization of membrane proteins that mediate direct interactions between different types of immune cells or between immune cells and cancer cells. Further the work of Dr. Bastings has established  links between multivalency and selectivity, and thereby revealing fundamental regulatory mechanisms of the immune system.

Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials. Hale Bila, Kaltrina Paloja, Vincenzo Caroprese, Artem Kononenko, Maartje M.C. Bastings, Journal of the American Chemical Society (JACS), 2022.

Significance of Receptor Mobility in Multivalent Binding on Lipid Membranes. D Morzy, M Bastings, Angewandte Chemie International Edition 61, 2022. 

DNA-Based Nanomaterials. Marianna M. Koga, Alice Comberlato, Hugo J. Rodríguez-Franco and Maartje M. C. Bastings, Biomacromolecules, 2022.