Lectures and seminars StratRegen Seminar Series with Helen Blau

Publications

Selective inhibition of stromal mechanosensing suppresses cardiac fibrosis.
Cho S, Rhee S, Madl CM, Caudal A, Thomas D, Kim H, Kojic A, Shin HS, Mahajan A, Jahng JW, Wang X, Thai PN, Paik DT, Wang M, Mullen M, Baker NM, Leitz J, Mukherjee S, Winn VD, Woo YJ, Blau HM, Wu JC
Nature 2025 Jun;642(8068):766-775

Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength.
Wang YX, Palla AR, Ho ATV, Robinson DCL, Ravichandran M, Markov GJ, Mai T, Still C, Balsubramani A, Nair S, Holbrook CA, Yang AV, Kraft PE, Su S, Burns DM, Yucel ND, Qi LS, Kundaje A, Blau HM
Cell Stem Cell 2025 Jul;32(7):1154-1169.e9

Hydrogel biomaterials that stiffen and soften on demand reveal that skeletal muscle stem cells harbor a mechanical memory.
Madl CM, Wang YX, Holbrook CA, Su S, Shi X, Byfield FJ, Wicki G, Flaig IA, Blau HM
Proc Natl Acad Sci U S A 2024 Aug;121(35):e2406787121

Regeneration of neuromuscular synapses after acute and chronic denervation by inhibiting the gerozyme 15-prostaglandin dehydrogenase.
Bakooshli MA, Wang YX, Monti E, Su S, Kraft P, Nalbandian M, Alexandrova L, Wheeler JR, Vogel H, Blau HM
Sci Transl Med 2023 Oct;15(717):eadg1485

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration.
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf KI, Frésard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM
Cell Stem Cell 2022 Dec;29(12):1653-1668.e8

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging.
Palla AR, Hilgendorf KI, Yang AV, Kerr JP, Hinken AC, Demeter J, Kraft P, Mooney NA, Yucel N, Burns DM, Wang YX, Jackson PK, Blau HM
Nat Commun 2022 Mar;13(1):1439

Sandwiches and coffee will be provided.