Lectures and seminars StratNeuro Lunch Seminar Series on the topic "Neuroepigenetics"

Topic: Neuroepigenetics

"Histone H3 mutations in cancer and neurodegeneration"

Nada Jabado, McGill University, Canada

Dr. Nada Jabado is a Professor of Pediatrics and Human Genetics at McGill University and a staff physician in the Division of Hematology and Oncology at the Montreal Children’s Hospital. She began her career as an independent investigator in 2003 at the RI-MUHC, pioneering a research program in pediatric brain tumors, which is now unparalleled. Dr. Jabado's group was among the first to identify a histone mutation in human disease which has revolutionized this field. The epigenome was a previously unsuspected hallmark of oncogenesis and this discovery linked development and what we now know are epigenetic-driven cancers.

Dr. Jabado has over 200 peer-reviewed publications to her credit in such prominent journals as Cell, Nature Genetics, Nature, Science and Cancer Cell.  She is invited as keynote speaker to International symposia and top ranked universities and has been awarded funding from CIHR, Genome Canada, NIH, as well as a Large-Scale Genomics grant from Genome Canada. In 2021, Dr. Jabado was awarded the Canadian Cancer Society's Robert L. Noble Prize, given for outstanding achievements in basic biomedical cancer research

Selected Publications

Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks.
Chaouch A, Berlandi J, Chen CCL, Frey F, Badini S, Harutyunyan AS, Chen X, Krug B, Hébert S, Jeibmann A, Lu C, Kleinman CL, Hasselblatt M, Lasko P, Shirinian M, Jabado N. Mol Cell. 2021 Oct 30:S1097-2765(21)00837-6. doi: 10.1016/j.molcel.2021.10.008

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA fro Gliomagenesis
Chen CCL#, Deshmukh S#, Jessa S#, Hadjadj D#, Lisi V, Andrade AF, Faury D, Jawhar W, Dali R, Suzuki H, Pathania M, A D, Dubois F, Woodward E, Hébert S, Coutelier M, Karamchandani J, Albrecht S, Brandner S, De Jay N, Gayden T, Bajic A, Harutyunyan AS, Marchione DM, Mikael LG, Juretic N, Zeinieh M, Russo C, Maestro N, Bassenden AV, Hauser P, Virga J, Bognar L, Klekner A, Zapotocky M, Vicha A, Krskova L, Vanova K, Zamecnik J, Sumerauer D, Ekert PG, Ziegler DS, Ellezam B, Filbin MG, Blanchette M, Hansford JR, Khuong-Quang DA, Berghuis AM, Weil AG, Garcia BA, Garzia L, Mack SC, Beroukhim R, Ligon KL, Taylor MD, Bandopadhayay P, Kramm C, Pfister SM, Korshunov A, Sturm D, Jones DTW, Salomoni P, Kleinman CL, Jabado N.
Cell. 2020 Dec 10;183(6):1617-1633.e22. doi: 10.1016/j.cell.2020.11.012. Epub 2020 Nov 30.

Stalled developmental programs at the root of pediatric brain tumors
Jessa S#, Blanchet-Cohen A#, Krug B, Vladoiu M, Coutelier M, Faury D, Poreau B, De Jay N, Hébert S, Monlong J, Farmer WT, Donovan LK, Hu Y, McConechy MK, Cavalli FMG, Mikael LG, Ellezam B, Richer M, Allaire A, Weil AG, Atkinson J, Farmer JP, Dudley RWR, Larouche V, Crevier L, Albrecht S, Filbin MG, Sartelet H, Lutz PE, Nagy C, Turecki G, Costantino S, Dirks PB, Murai KK, Bourque G, Ragoussis J, Garzia L, Taylor MD, Jabado N*, Kleinman CL*.
Nat Genet. 2019 Dec;51(12):1702-1713.doi: 10.1038/s41588-019-0531-7. Epub 2019 Nov 25.

"PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons"

Johan Holmberg, Karolinska Institutet, Department of Cell and Molecular Biology

Dr. Johan Holmberg is a Professor at the Department of Molecular Biology at the University of Umeå, Sweden. Prof. Holmberg started his research group in 2009 at Karolinska Institutet, where he became Associate Professor in 2009, before being appointed Professor of Molecular Tumor Biology at the University of Umeå.

Prof. Holmberg’s group is interested in two fundamental questions: How is neuronal identity acquired during development and subsequently maintained in the adult? How do errors in the mechanisms governing neuronal differentiation and maintenance affect tumor formation and degenerative processes in the nervous system?

Selected Publications:

PRC2-mediated repression is essential to maintain identity and function of differentiated dopaminergic and serotonergic neurons
Toskas, K., Yaghmaeian-Salmani, B., J., Skiteva, O., Paslawski, W., Gilberg, L., Skara, V., Antoniou, I., Södersten, E., Svenningsson, P., Chergui, K., Ringnér, M., Perlmann, T, and Holmberg, J.§ (2022).
Science Advances 2022 Aug 26;8(34):eabo1543 

A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
Södersten, E§., Toskas, K., Rraklli, V., Tiklova, K., Björklund, Å., Ringnér, M., Perlmann, T. and Holmberg, J§. (2018).
Nat Commun. 2018 Mar 26;9(1):1226.

Reply to Mohlin et al.: High levels of EPAS1 are closely associated with key features of low-risk neuroblastoma
Westerlund, I., Shi, Y., Toskas, K., Fell, SM., Li, S., Södersten, E., Schlisio, S. and Holmberg, J§. (2017).
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10859-E10860.

CHD5 is required for neurogenesis and has a dual role in facilitating gene expression and Polycomb gene repression
Egan, CM., Nyman, U., Skotte, J., Streubel, G., Turner, S., O'Connell, DJ., Rraklli, V., Dolan, MJ., Chadderton, N., Hansen, K., Farrar, GJ., Helin, K., Holmberg, J.§ and Bracken, AP§ (2013). 
Developmental Cell, 26(3), 223-226.

Host

Gonçalo Castelo-Branco, Karolinska Institutet, Department of Medical Biochemistry and Biophysics

Sandwiches and coffee will be provided after the seminar for those attending onsite.