Conferences and symposiums Stockholm Proteostasis Network
Mini-symposium jointly organized by Karolinska Institutet, Stockholm University and KTH Royal Institute of Technology.
Advanced studies of the proteostasis system
Monday, Sep 5th 9:00-16:00
Proteostasis research studies the integrated events and mechanisms of the proteostasis system that maintain the cellular and organismal proteomes functional. This includes protein biogenesis, protein folding, quality control, stress responses, protein aggregates and proteolytic systems (ubiquitin-proteasome system and autophagy). Failure of these mechanisms are associated with decreased organismal fitness and disease. The proteostasis field is of central importance for biological and biomedical research. This course aims at providing an up-to-date overview of ongoing contemporary research on the proteostasis system, focusing on the key research questions and approaches that currently are undertaken.
Keynote speaker: Prof. Markus Tamas, University of Gothenburg
Symposium venue: Stockholm University, Vivi Täckholmsalen, Svante Arrhenius väg 20A, 114 18 Stockholm
9.00 – 9.10 Welcome by Maria Gierisch and Joydeep Roy (organizing committee)
9.10 – 9.50 Keynote lecture
Prof. Markus J. Tamás, Department of Chemistry & Molecular Biology, University of Gothenburg
Proteostasis and protein quality control during heavy metal stress
While the toxicity of metals and metalloids, like arsenic, cadmium, mercury, lead and chromium, is undisputed, the underlying molecular mechanisms are not entirely clear. Consensus holds that proteins are the prime targets; heavy metals interfere with the physiological activity of specific, particularly susceptible proteins, either by forming a complex with functional side chain groups or by displacing essential metal ions in metalloproteins. Recent studies have revealed an additional mode of metal action targeted at proteins in a non-native state; certain heavy metals and metalloids including cadmium and arsenic have been found to inhibit the in vitro refolding of chemically denatured proteins, to interfere with protein folding in vivo, and to cause misfolding and aggregation of nascent proteins in living cells. Thus, by interfering with the folding process, heavy metal ions and metalloids profoundly affect protein homeostasis and cell viability. My talk will highlight our work on how arsenic and cadmium interfere with protein folding and trigger widespread protein aggregation in living cells. I will also describe mechanisms by which cells regulate quality control systems to protect from heavy metal/metalloid toxicity.
9.50 - 10.10 Axel Leppert KI
“Self-assembly of NPM1 regulates the chaperone activity of the nucleolus”
10.10 - 10.30 Makoto Shimozawa KI
“A link between autophagy impairment and synaptic dysfunction in hippocampus of App knock-in Alzheimer mouse models”
10.30-11.00 Morning fika break
11.00 - 11.20 Deike Omnus SU
“A novel heat shock protein activates the Lon protease at the onset of proteotoxic stress”
11.20 - 11.40 Shady Kamal KI
“FtsH protease confers fitness advantages to the worldwide prevalent Pseudomonas aeruginosa clone C”
11.40 - 12.00 Jiangnan Liu KI
“Remodeling of the ribosomal quality control and protein translation by a viral ubiquitin deconjugase”
12.00 - 13.00 Lunch
13.00 - 13.20 Justin Westerfield SU
“Co-translational folding of the voltage-gated potassium channel, KvAP”
13.20 - 13.40 Samu Himanen Åbo Akademi
“HSFs drive distinct transcription programs upon oxidative stress and heat shock”
13.40 - 14.00 Jianing Liu KI
“The role of the chain-specific deubiquitinase in intestinal homeostasis and colorectal cancer”
14.00-14.20 Afternoon fika break
14.20-14.40 Laurène Adam KI
To be announced
14.40-15.00 Xuexin Li KI
“A chemical screen to identify novel drugs for the treatment of Huntington’s disease"
15.00-15.20 Aljona Maljukova KI
“Wee1 kinase inhibition reveals drug targetable vulnerabilities in acute B-lymphoblastic leukemia”
15.20-15.40 Nicholas Valerie KI
“Coupling drug-target engagement to downstream biology with CeTEAM”
15.40-16.00 Concluding remarks by Nico Dantuma and Claes Andréasson
The mini-symposium is listed as a course at Stockholm University. Credits can be obtained (0.5 credits for active participation, 1.5 credits for active participation and scientific presentation).