Lectures and seminars SFOepi Seminar Series in Biostatistics: Andrea Ganna, University of Helsinki
Title: Disease prediction using nation-wide health data and genetics.
Please note that this event is not filmed nor streamed – only participation in person.
Abstract
Utilising data from Finland, where genetic details of approximately 500,000 individuals are linked to a national health registry, this presentation will explore the use of polygenic scores and electronic health records (EHRs) to predict disease susceptibility. It will highlight the challenges and successes of employing polygenic scores for disease prediction. Additionally, the talk will discuss the application of machine learning algorithms to predict healthcare outcomes from EHRs, assessing their fairness and generalizability across different populations. The presentation will conclude with a direct comparison of genetic and EHR-based predictions to assess which approach is most predictive and generalizable across healthcare systems.
About the speaker
Andrea is an associate professor at Helsinki Institute of Life Science HiLIFE at University of Helsinki and an instructor at Harvard Medical School and Massachusetts General Hospital. He did his PhD at Department of Medical Epidemiology and Biostatistics, Karolinska Institutet and a post-doc at the Analytical and Translation Genetic Unit at Massachusetts General Hospital/Harvard Medical School/Broad Institute. His research interests lie on the intersection between epidemiology, genetics and statistics. Andrea have authored and co-authored both methodological and applied papers focused on leveraging large scale epidemiological datasets to identify novel socio-demographic, metabolic and genetic markers of common complex diseases. He has extensive expertise in statistical genetics and have been working with large-scale exome and genome sequencing data, focusing on ultra-rare variants in coding and non-coding regions. His research vision is to integrate genetic data and information from electronic health record/national health registries to enhance early detection of common diseases and public health interventions.
Registration: No registration is needed
If you have any questions, please contact Marie Jansson at marie.jansson@ki.se