Lectures and seminars Seminar: "The needs of a synapse - how secretory lysosomes serve synaptic proteostasis"
Welcome to a seminar with Dr Katarzyna Grochowska from the Center for Molecular Neurobiology Hamburg, Germany.
Title
"The needs of a synapse - how secretory lysosomes serve synaptic proteostasis"
Speaker
Dr Grochowska is currently a postdoc in Dr Michael R. Kreutz’s lab at the Center for Molecular Neurobiology Hamburg, Germany, where she investigates the mechanisms of neuronal protein homeostasis and discovered a previously unknown cellular mechanism that controls dendritic metastable protein concentration and shapes the structure of the excitatory synapse. She was awarded a European Research Council Starting Grant in 2024.
Dr Grochowska earned a Master of Biotechnology degree at Warsaw University of Life Sciences, Poland, and a PhD at the Leibniz Institute for Neurobiology, Germany, where she investigated the neuronal excitation-transcription coupling mechanisms and their alterations in neurodegenerative diseases, uncovering how the synapto-nuclear messenger protein Jacob drives synaptic impairment.
Selected publications
Wirth S, Schlößer A, Beiersdorfer A, Schweizer M, Woo MS, Friese MA, Lohr C, Grochowska KM. (2024). Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling. Glia, 72(8):1451-1468. doi: 10.1002/glia.24539.
Grochowska KM, Sperveslage M, Raman R, Failla AV, Głów D, Schulze C, Laprell L, Fehse B, Kreutz MR. (2023). Chaperone-mediated autophagy in neuronal dendrites utilizes activity-dependent lysosomal exocytosis for protein disposal. Cell Rep., 42(8):112998. doi: 10.1016/j.celrep.2023.112998
Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR. (2023). Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. EMBO J., 42(4):e112453. doi: 10.15252/embj.2022112453.
Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. (2017). Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Rep., 18(6):962-981. doi: 10.15252/embr.201643519.
Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. (2016). A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics, 12(3):e1005907. doi: 10.1371/journal.pgen.1005907.
Host
MBB Faculty / MBB Frontier Grant Recruitment