Lectures and seminars Seminar: "The nanoscale architecture of intracellular lipid fluxes"

Title

"The nanoscale architecture of intracellular lipid fluxes"

Speaker

Dr Salo is currently a postdoc in Dr Julia Mahamid’s lab at EMBL Heidelberg, Germany, where he focuses on combining advanced cell biological and cryo-correlative light and electron microscopy (cryo-CLEM) methodologies to decipher the nanoscale architecture of organelle biogenesis in the endoplasmic reticulum of human cells.

Dr Salo completed his MD studies at the University of Helsinki, Finland, where he also earned his PhD in Dr Elina Ikonen’s lab, researching intracellular lipid fluxes and developing new methods for tracing fatty acids.

Selected publications

Fung HKH, Hayashi Y, Salo VT, Babenko A, Zagoriy I, Brunner A, Ellenberg J, Müller CW, Cuylen-Haering S, Mahamid J. (2023) Genetically encoded multimeric tags for subcellular protein localization in cryo-EM. Nature Methods, 20(12):1900-1908. doi: 10.1038/s41592-023-02053-0. 

Combot Y, Salo VT, Chadeuf G, Hölttä M, Ven K, Pulli I, Ducheix S, Pecqueur C, Renoult O, Lak B, Li S, Karhinen L, Belevich I, Le May C, Rieusset J, Le Lay S, Croyal M, Tayeb KS, Vihinen H, Jokitalo E, Törnquist K, Vigouroux C, Cariou B, Magré J, Larhlimi A, Ikonen E, Prieur X. (2022) Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes. Cell Rep., 38(2):110213. doi: 10.1016/j.celrep.2021.110213. 

Prasanna X, Salo VT, Li S, Ven K, Vihinen H, Jokitalo E, Vattulainen I, Ikonen E. (2021) Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane. PLoS Biology, 19(1):e3000998. doi: 10.1371/journal.pbio.3000998. 

Salo VT, Li S, Vihinen H, Hölttä-Vuori M, Szkalisity A, Horvath P, Belevich I, Peränen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR, Jokitalo E, Ikonen E. (2019) Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Edoplasmic Reticulum Contact. Dev Cell., 50(4):478-493.e9. doi: 10.1016/j.devcel.2019.05.016. 

Salo VT, Belevich I, Li S, Karhinen L, Vihinen H, Vigouroux C, Magré J, Thiele C, Hölttä-Vuori M, Jokitalo E, Ikonen E. (2016) Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J., 35(24):2699-2716. doi: 10.15252/embj.201695170. 

Host

MBB Faculty / MBB Frontier Grant Recruitment