Lectures and seminars Seminar: Sleep disruption by cannabis and alcohol in murine models

Speaker 

Professor David Lovinger, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, USA

Title

Sleep disruption by cannabis and alcohol in murine models

Summary 

"Cannabinoids and alcohol are often used by humans to promote sleep, but clinical studies indicate that tolerance develops to these somnolescent drug effects. Furthermore, sleep is disrupted during abstinence following chronic drug exposure. Indeed, disordered sleep makes a substantial contribution to substance use disorders. We are exploring the neural mechanisms involved in sleep promotion and disruption by delta-9-tetrahydrocannabinol (THC) and ethanol in mice. In this talk I will describe our establishment of exposure and spontaneous forced abstinence paradigms for both drugs, combined with polysomnographic sleep recordings. I will then present studies examining behavioral changes and neural changes in the basal ganglia and medial septum related to drug exposure and sleep disruption during abstinence. Strategies to prevent or reverse drug-induced sleep disruption will be explored."

Place 

BioClinicum, J3:11 Birger & Margareta Blombäck

Time

7th November at 10.00 – 11.00.

More:

Follows by the seminar Dopamine and Striatal Microcircuits in Action Selection (11.00 – 12.00.)