Lectures and seminars Seminar: Sleep disruption by cannabis and alcohol in murine models

07-11-2022 10:00 am - 11:00 am Add to iCal
Karolinska University Hospital, Solna BioClinicum, J3:11 Birger & Margareta Blombäck

Welcome to a seminar with Professor David Lovinger, tiled "Sleep disruption by cannabis and alcohol in murine models".

Profile picture of guest researcher David Lovinger
Professor David Lovinger


Professor David Lovinger, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Rockville, USA


Sleep disruption by cannabis and alcohol in murine models


"Cannabinoids and alcohol are often used by humans to promote sleep, but clinical studies indicate that tolerance develops to these somnolescent drug effects. Furthermore, sleep is disrupted during abstinence following chronic drug exposure. Indeed, disordered sleep makes a substantial contribution to substance use disorders. We are exploring the neural mechanisms involved in sleep promotion and disruption by delta-9-tetrahydrocannabinol (THC) and ethanol in mice. In this talk I will describe our establishment of exposure and spontaneous forced abstinence paradigms for both drugs, combined with polysomnographic sleep recordings. I will then present studies examining behavioral changes and neural changes in the basal ganglia and medial septum related to drug exposure and sleep disruption during abstinence. Strategies to prevent or reverse drug-induced sleep disruption will be explored."


BioClinicum, J3:11 Birger & Margareta Blombäck


7th November at 10.00 – 11.00.


Follows by the seminar Dopamine and Striatal Microcircuits in Action Selection (11.00 – 12.00.)


Karima Chergui Senior Lecturer