Lectures and seminars Seminar: SARS-CoV-2 humoral immune responses after near-universal prior infection, in a high HIV prevalence region
Welcome to a seminar by Professor Penny Moore from the University of Witwatersrand in Johannesburg.
Relevant publications
Richardson SI, Madzorera VS, Spencer H, Manamela NP, van der Mescht M, Lambson B, Oosthuysen B, Ayres F, Molaudzi Z, Moyo-Gwete T, Mzindle N, Motlou T, Mendes A, Tegally H, Venter M, de Oliveira T, Ueckermann V, Rossouw TM, Boswell MT, Moore. PL. (2022) SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals. Cell Host and Microbe, 30(6):880-886.e4
Madhi SA, Kwatra G, Richardson SI, Koen AL, Baillie V, Cutland CL, Fairlie L, Padayachee SH, Dheda K, Barnabas SL, Bhorat QE, Briner C, Ahmed K, Aley PK, Bhikha S, Bhorat AE, Esmail A, Horne E, Kaldine H, Mukendi CK, Madzorera VS, Manamela NP, Masilela M, Hermanus T, Motlou T, Mzindle N, Oelofse S, Patel F, Rhead S, Rossouw L, Taoushanis C, van Eck S, Lambe T, Gilbert S, Pollard AJ, Moore PL, Izu A. (2022) Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including Omicron BA.1 and BA.4 six months after vaccination: a randomised, phase 1b/2a trial. The Lancet Infectious Diseases, S1473-3099(22)00596-5
Kitchin D*, Richardson SI*, van der Mescht, Motlou T, Mzindle N, Moyo-Gwete T, Makhado Z, Ayres F, Manamela NP, Spencer H, Lambson BE, Oosthuysen B, Mennen M, Skelem S, Williams N, Ntusi NAB, Burgers WA, Gray GG, Bekker L, Boswell MT, Rossouw TM, Ueckermann V, Moore PL. (*Equal contribution) Ad26.COV2.S breakthrough infections induce high titers of antibodies against Omicron and other SARS-CoV-2 variants of concern. Cell Reports Medicine, 3(3): 100535
Keeton R, Richardson SI, Moyo-Gwete T, Hermanus T, Tincho MB, Benede N, Manamela NP, Baguma R, Makhado Z, Ngomti A, Motlou T, Mennen M, Chinhoyi L, Skelem S, Maboreke H, Doolabh D, Iranzadeh A, Otter A, Brooks T, Noursadeghi M, Moon J, Blackburn J, Hsiao N, Williamson C, Riou C, Gogo A, Garrett N, Bekker L, Gray G, *Ntusi NAB, *Moore PL, *Burgers WA. (*joint senior authors). (2021) Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant dependent manner. Cell Host Microbe, 29(11):1611-1619.e5