Lectures and seminars Seminar: "Metabolic crosstalk in the muscle” with Prof. Katrien De Bock, ETH Zürich

Speaker

Prof. Katrien De Bock, Department of Health Sciences and Technology, ETH Zürich, Switzerland

Katrien De Bock is a full Professor at the Department of Health Sciences and Technology and a member of the Institute for Human Movement Sciences and Sport at ETH Zürich. The De Bock laboratory focuses on investigating how endothelial cells rewire their metabolism during angiogenesis and how they metabolically communicate with other cell types in the muscle microenvironment to maintain or establish muscle homeostasis. Specific interest goes to deciphering mechanisms of blood vessel growth and endothelial metabolic crosstalk in the muscle following exercise and/or muscle injury. 

Title 

“Metabolic crosstalk in the muscle”

Key publications

Endothelial metabolic control of insulin sensitivity through resident macrophages Zhang J, Sjøberg KA, Gong S, Wang T, Li F, Kuo A, Durot S, Majcher A, Ardicoglu R, Desgeorges T, Mann CG, Soro Arnáiz I, Fitzgerald G, Gilardoni P, Abel ED, Kon S, Olivares-Villagómez D, Zamboni N, Wolfrum C, Hornemann T, Morscher R, Tisch N, Ghesquière B, Kopf M, Richter EA, De Bock K. Cell Metab. 2024 Nov 5;36(11):2383-2401.e9. 

Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration

Desgeorges T, Galle E, Zhang J, von Meyenn F, De Bock K. 
Mol Metab. 2024 May;83:101923

Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

Fan Z, Turiel G, Ardicoglu R, Ghobrial M, Masschelein E, Kocijan T, Zhang J, Tan G, Fitzgerald G, Gorski T, Alvarado-Diaz A, Gilardoni P, Adams CM, Ghesquière B, De Bock K. Cell Metab. 2021 Sep 7;33(9): 1793-1807.e9.

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni-Barrera R, Masschelein E, D'Hulst G, Gilardoni P, Turiel G, Fan Z, Wang T, Planque M, Carmeliet P, Pellerin L, Wolfrum C, Fendt SM, Banfi A, Stockmann C, Soro-Arnáiz I, Kopf M, De Bock K. Cell Metab. 2020 Jun 2;31(6):1136-1153.e7. 

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

D’Hulst G, Soro-Arnaiz I, Masschelein E, Veys K, Fitzgerald G, Smeuninx B, Kim S, Deldicque L, Blaauw B, Carmeliet P, Breen L, Koivunen P, Zhao S-M, De Bock K.  Nat Commun 2020 11:174

Contact

Ingrid Nilsson, Department of Medical Biochemistry and Biophysics

ingrid.nilsson@ki.se