Lectures and seminars Seminar: "Epigenetics of sex differences"
Welcome to a seminar with Prof. Claudia Isabelle Keller Valsecchi, University of Basel, Switzerland.
Prof. Claudia Isabelle Keller Valsecchi from the University of Basel investigates how cells control gene dosage alterations during evolution and disease. Her research focuses on the epigenetic and molecular mechanisms that balance gene expression between sexes, from chromosome-wide dosage compensation to tissue-specific regulation of the X chromosome. By integrating evolutionary and comparative approaches across species, her work reveals how dosage control shapes development, sex differences, and disease susceptibility.
In addition to her talk at KI, Prof. Valsecchi will be the opponent of PhD candidate Natali Papanicolou’s defense taking place at 9:30 on the same day in Atrium, Nobels väg 12b.
Key Publications
Convergent evolution of H4K16ac-mediated dosage compensation in the ZW species Artemia franciscana
F Zimmer, AM Fox, Q Pan, FF Rühle, P Andersen, A-K Huylmans, T Schwander, MF Basilicata, CIK Valsecchi
The sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes
AI Kalita, E Marois, M Kozielska, FJ Weissing, E Jaouen, MM Möckel, FR Rühle, F Butter, MF Basilicata, CIK Valsecchi
RNA nucleation by MSL2 induces selective X chromosome compartmentalization
CIK Valsecchi, MF Basilicata, P Georgiev, A Gaub, J Seyfferth, T Kulkarni, A Panhale, G Semplicio, V Manjunath, H Holz, P Dasmeh, A Akhtar
Speaker homepage
Valsecchi lab, University of Basel
Contact
Björn Reinius bjorn.reinius@ki.se
Natali Papanicolaou natali.papanicolaou@ki.se
Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet