Lectures and seminars Seminar: ”Directing Cell Fate, Maturation, and Brain Repair using Human Stem Cells”
Welcome to a seminar with Professor Lorenz Studer from Memorial Sloan Kettering Cancer Center, New York.
Title
"Directing Cell Fate, Maturation, and Brain Repair using Human Stem Cells”
Speaker
Prof. Lorenz Studer, Memorial Sloan Kettering Cancer Center, New York
Prof. Studer will be the faculty opponent at the PhD thesis defense of Emilía Sif Ásgrímsdóttir, from Prof. Ernest Arenas research group, Friday January 24th, 2025, at 9:00 in Andreas Vesalius Hall, Karolinska Institutet.
Lorenz Studer is the founder and director of the Center for Stem Cell Biology at Memorial Sloan Kettering Cancer Center. Lorenz Studer’s research group aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and application of human embryonic stem and human induced pluripotent cells. Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine.
Selected Publications
Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons. Cell. 2024 Jul 11;187(14):3671-3689.e23. doi: 10.1016/j.cell.2024.05.030. Epub 2024 Jun 11. PMID: 38866017
Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Jan 31. doi: 10.1038/s41586-023-06984-8. PMID: 38297124
Hergenreder E, Minotti AP, Zorina Y, Oberst P, Zhao Z, Munguba H, Calder EL, Baggiolini A, Walsh RM, Liston C, Levitz J, Garippa R, Chen S, Ciceri G, Studer L. Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-02031-z. PMID: 38168993
Kim TW, Piao J, Koo SY, Kriks S, Chung SY, Betel D, Socci ND, Choi SJ, Zabierowski S, Dubose BN, Hill EJ, Mosharov EV, Irion S, Tomishima MJ, Tabar V, Studer L. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021 Feb 4;28(2):343-355.e5. doi: 10.1016/j.stem.2021.01.005.PMID: 33545081
Host
Prof. Gonçalo Castelo-Branco, Department of Medical Biochemistry and Biophysics, Karolinska Institutet.