Lectures and seminars Seminar: Cooling newborn infants after hypoxic ischemic injury - limitations and advances over the last 30 years
The Physiology Society is hosting a seminar with Professor Marianne Thoresen, Institute of Basic Medical Sciences, University of Oslo, Norge. Wednesday September 29th, 2001 at 4.15 pm.
Cooling newborn infants after hypoxic ischemic injury - limitations and advances over the last 30 years
In the term newborn, the main cause of global developmental delay with or without concomitant cerebral palsy is global reduction in brain oxygenation and/or perfusion. Problems in the perinatal period like obstructed labor and delayed delivery, massive bleeds from the placenta, umbilical cord around the neck, infection and other reasons causes this hypoxic-ischemic injury.
Marianne Thoresen has since the early nineties studied the neuroprotective effect of post-insult hypothermia in newborn animal models leading to successful international randomized clinical trials. World-wide, such trials were ongoing between 1999 and 2007 and then in 2010, international guidelines (Ilcor) recommended therapeutic hypothermia as standard neonatal care after hypoxic –ischemic insults. Fifteen years of clinical cooling have further improved outcome as compared to the early trials in some, but not all regions. There are many unanswered questions regards key cellular pathways and optimal delivery of therapeutic hypothermia as well as additional treatment strategies. Marianne has led the cooling program in Bristol, UK since 1998. Current result from cooling 400 asphyxiated babies, 75% have good outcome as compared 49% in the trials. This includes a reduction in mortality from 30 to 10%.
Host: Hugo Lagercrantz