Lectures and seminars Research Lecture at Nobel Forum with Mike Stratton
Welcome to a research lecture with Professor Sir Mike Stratton, Director of the Wellcome Sanger Institute and Chief Executive Officer of the Wellcome Genome Campus, Hinxton, Cambridgeshire. The lecture has the title "Mutations in normal cells".
The host of the lecture is Klas Wiman, Professor of Molecular Cell and Tumor Biology at the Department of Oncology-Pathology at Karolinska Institutet.
After the lecture refreshments will be served in the Gallery at Nobel Forum.
About the lecture
Title: Mutations in normal cells
Mutations in DNA/RNA cause the phenotypic variation upon which natural selection acts during evolution. Mutations arise and are transmitted between generations of organisms and between generations of cells in the somatic tissues of multicellular organisms. However, our knowledge of the biological processes that generate mutations and the rates at which they occur in different normal cell types has been rudimentary until recently. Cancer is a recognized consequence of somatic mutations. However, we have limited understanding of other potential outcomes. I will review our current understanding of the landscape of somatic mutations in normal cells, considering their causes and consequences.