Lectures and seminars Presentation by Professor Yasuyuki Fujita
Cell competition between normal and transformed epithelial cells
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Professor Yasuyuki Fujita will present his research on how cancer cells compete with normal epithelial cells. Organized by Stockholm Liver Metastases Research Network, supported by Cancer Research KI.
Host: Marco Gerling
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Key publications
Igarashi, N., Miyata, K., Loo, T.M. et al. Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells. Nat Commun 13, 4157 (2022).
Ayukawa, S., Kamoshita, N., Nakayama, J. et al. Epithelial cells remove precancerous cells by cell competition via MHC class I–LILRB3 interaction. Nat Immunol 22, 1391–1402 (2021).
Shunsuke Kon, Yasuyuki Fujita. Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis, Developmental Biology, Volume 476, 2021. Hogan, C., Dupré-Crochet, S., Norman, M. et al. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 11, 460–467 (2009).