Lectures and seminars Pediatric Oncology seminar 20/4

Speaker

Malin Lönnerblad, PhD, Department of Women’s and Children’s Health, Uppsala University and Karolinska Institutet, and Department of Special Education, Stockholm University.  

Title

"Educational and occupational outcomes in teenagers and young adults treated for brain tumors in childhood "

Summary

Further education following the nine years of compulsory school and occupational outcomes, including employment, sickness or activity compensation, and parental leave was explored in two registry-based studies including 452 Swedish pediatric brain tumor survivors, born 1988–1996, and diagnosed with a brain tumor before their 15th birthday. Their results were compared with 2188 matched controls. Results showed that significantly fewer teenagers and young adults treated for brain tumors in childhood attended high school or university compared with controls and there were also significant differences between cases and controls for all assessed variables concerning occupational outcomes. 

Speaker

Christina Egnell Gustafsson, MD, PhD student (Susanna Ranta group) 

Title

"The effect of BMI on HD-MTX pharmacokinetics and associated toxicity in children with ALL"

Summary

Obese children with acute lymphoblastic leukemia (ALL) have an increased risk of relapse and lower survival rates. The underlying causes are unknown; one contributing factor could be aberrant pharmacokinetics of chemotherapeutic agents with extreme body weight. High-dose methotrexate (HD-MTX) is a key component in ALL treatment. Yet, there is a large inter- and intra-individual variation in the HD-MTX excretion and it associates with several toxicities. In this study we investigate the impact of body mass index (BMI) on excretion of 5g/m2 HD-MTX and HD-MTX-related toxicity in children treated with NOPHO ALL2008 protocol. 

Moderator

Kleopatra Georgantzi