Lectures and seminars Opponent seminar - Prof. Ian D. Hickson, University of Copenhagen

Welcome to the opponent seminar with Professor Ian D. Hickson Director, Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen   

Host: Laura Baranello 
Venue: Biomedicum Room D1012 
Date: November 11 at 15.00 
Title: “Biophysical & cellular analysis of mitotic human chromosomes” 

Prof. Hickson research focuses on gene defects that can lead to premature ageing and age-associated diseases such as cancer. Prof. Hickson has made important discoveries about DNA repair in cells and is known for cloning several bacterial and human DNA repair genes. He was the first to characterize the BLM helicase, which is defective in a rare condition called Bloom syndrome associated with a raised incidence of many cancers. In recent years, he has increasingly been using optical tweezers to conduct single molecule biochemistry and analysis of human chromosomes. 
 

Key publications: 
RAD51 protects human cells from transcription-replication conflicts.
Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID
Mol Cell 2022 Sep;82(18):3366-3381.e9

Nonlinear mechanics of human mitotic chromosomes.
Meijering AEC, Sarlós K, Nielsen CF, Witt H, Harju J, Kerklingh E, Haasnoot GH, Bizard AH, Heller I, Broedersz CP, Liu Y, Peterman EJG, Hickson ID, Wuite GJL
Nature 2022 May;605(7910):545-550

PICH and TOP3A cooperate to induce positive DNA supercoiling.
Bizard AH, Allemand JF, Hassenkam T, Paramasivam M, Sarlós K, Singh MI, Hickson ID
Nat Struct Mol Biol 2019 Apr;26(4):267-274